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Impact of neoadjuvant and adjuvant radiotherapy on disease-specific survival in patients with stages II–IV rectal cancer

OBJECTIVES: The purposes of this study were to determine whether neoadjuvant or adjuvant radiotherapy affected disease-specific survival (DSS) in patients with rectal cancer and whether stratification by tumor stage affected the results. RESULTS: 55.5% patients had neoadjuvant-radiotherapy (NRT), an...

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Autores principales: Wu, Yinying, Liu, Haiyang, Du, Xianglin L., Wang, Fan, Zhang, Jing, Cui, Xiaohai, Li, Enxiao, Yang, Jin, Yi, Min, Zhang, Yunfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739784/
https://www.ncbi.nlm.nih.gov/pubmed/29290999
http://dx.doi.org/10.18632/oncotarget.22460
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author Wu, Yinying
Liu, Haiyang
Du, Xianglin L.
Wang, Fan
Zhang, Jing
Cui, Xiaohai
Li, Enxiao
Yang, Jin
Yi, Min
Zhang, Yunfeng
author_facet Wu, Yinying
Liu, Haiyang
Du, Xianglin L.
Wang, Fan
Zhang, Jing
Cui, Xiaohai
Li, Enxiao
Yang, Jin
Yi, Min
Zhang, Yunfeng
author_sort Wu, Yinying
collection PubMed
description OBJECTIVES: The purposes of this study were to determine whether neoadjuvant or adjuvant radiotherapy affected disease-specific survival (DSS) in patients with rectal cancer and whether stratification by tumor stage affected the results. RESULTS: 55.5% patients had neoadjuvant-radiotherapy (NRT), and 18.3% patients had adjuvant- radiotherapy (ART). Multivariable models showed that treatment type was independently associated with DSS. Patients with stages III/IV tumors who received ART plus chemotherapy had significantly worse DSS than did those who received NRT plus chemotherapy (NCRT) (P = 0.03). Among patients with stage II tumors, those who received ART plus chemotherapy and those who received NCRT had similar DSS. Further stratification by risk group revealed that patients with stage IIIA tumors who received ART plus chemotherapy had significantly better DSS than did those who received NCRT (P = 0.04). The ART plus chemotherapy and NCRT groups had similar DSS in patients with stage IIA tumors. Among high-risk patients (T3N+/T4), the NCRT group had significantly better DSS than did the ART plus chemotherapy group. Patients who underwent surgery only had the worst DSS of all the treatment groups. MATERIALS AND METHODS: From the Surveillance, Epidemiology, and End Results database, patients diagnosed with stages II–IV rectal cancer from 2004–2014 were identified. Clinicopathologic features, treatments, and DSS in different treatment groups were compared. CONCLUSIONS: NCRT or ART plus chemotherapy can reduce deaths from rectal cancer. Patients with stage IIIA tumors will benefit most from ART plus chemotherapy, whereas NCRT should be recommended to patients with stages II, IIIB, or higher tumors.
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spelling pubmed-57397842017-12-29 Impact of neoadjuvant and adjuvant radiotherapy on disease-specific survival in patients with stages II–IV rectal cancer Wu, Yinying Liu, Haiyang Du, Xianglin L. Wang, Fan Zhang, Jing Cui, Xiaohai Li, Enxiao Yang, Jin Yi, Min Zhang, Yunfeng Oncotarget Research Paper OBJECTIVES: The purposes of this study were to determine whether neoadjuvant or adjuvant radiotherapy affected disease-specific survival (DSS) in patients with rectal cancer and whether stratification by tumor stage affected the results. RESULTS: 55.5% patients had neoadjuvant-radiotherapy (NRT), and 18.3% patients had adjuvant- radiotherapy (ART). Multivariable models showed that treatment type was independently associated with DSS. Patients with stages III/IV tumors who received ART plus chemotherapy had significantly worse DSS than did those who received NRT plus chemotherapy (NCRT) (P = 0.03). Among patients with stage II tumors, those who received ART plus chemotherapy and those who received NCRT had similar DSS. Further stratification by risk group revealed that patients with stage IIIA tumors who received ART plus chemotherapy had significantly better DSS than did those who received NCRT (P = 0.04). The ART plus chemotherapy and NCRT groups had similar DSS in patients with stage IIA tumors. Among high-risk patients (T3N+/T4), the NCRT group had significantly better DSS than did the ART plus chemotherapy group. Patients who underwent surgery only had the worst DSS of all the treatment groups. MATERIALS AND METHODS: From the Surveillance, Epidemiology, and End Results database, patients diagnosed with stages II–IV rectal cancer from 2004–2014 were identified. Clinicopathologic features, treatments, and DSS in different treatment groups were compared. CONCLUSIONS: NCRT or ART plus chemotherapy can reduce deaths from rectal cancer. Patients with stage IIIA tumors will benefit most from ART plus chemotherapy, whereas NCRT should be recommended to patients with stages II, IIIB, or higher tumors. Impact Journals LLC 2017-11-06 /pmc/articles/PMC5739784/ /pubmed/29290999 http://dx.doi.org/10.18632/oncotarget.22460 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wu, Yinying
Liu, Haiyang
Du, Xianglin L.
Wang, Fan
Zhang, Jing
Cui, Xiaohai
Li, Enxiao
Yang, Jin
Yi, Min
Zhang, Yunfeng
Impact of neoadjuvant and adjuvant radiotherapy on disease-specific survival in patients with stages II–IV rectal cancer
title Impact of neoadjuvant and adjuvant radiotherapy on disease-specific survival in patients with stages II–IV rectal cancer
title_full Impact of neoadjuvant and adjuvant radiotherapy on disease-specific survival in patients with stages II–IV rectal cancer
title_fullStr Impact of neoadjuvant and adjuvant radiotherapy on disease-specific survival in patients with stages II–IV rectal cancer
title_full_unstemmed Impact of neoadjuvant and adjuvant radiotherapy on disease-specific survival in patients with stages II–IV rectal cancer
title_short Impact of neoadjuvant and adjuvant radiotherapy on disease-specific survival in patients with stages II–IV rectal cancer
title_sort impact of neoadjuvant and adjuvant radiotherapy on disease-specific survival in patients with stages ii–iv rectal cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739784/
https://www.ncbi.nlm.nih.gov/pubmed/29290999
http://dx.doi.org/10.18632/oncotarget.22460
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