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Increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from EEG data

Schizophrenia is often considered to be a disconnection syndrome. The abnormal interactions between large-scale functional brain networks result in cognitive and perceptual deficits. The present study investigated event-related functional connectivity networks to compare facial processing in individ...

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Autores principales: Yan, Tianyi, Wang, Wenhui, Liu, Tiantian, Chen, Duanduan, Wang, Changming, Li, Yulong, Ma, Xudong, Tang, Xiaoying, Wu, Jinglong, Deng, Yiming, Zhao, Lun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739816/
https://www.ncbi.nlm.nih.gov/pubmed/29291031
http://dx.doi.org/10.18632/oncotarget.20598
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author Yan, Tianyi
Wang, Wenhui
Liu, Tiantian
Chen, Duanduan
Wang, Changming
Li, Yulong
Ma, Xudong
Tang, Xiaoying
Wu, Jinglong
Deng, Yiming
Zhao, Lun
author_facet Yan, Tianyi
Wang, Wenhui
Liu, Tiantian
Chen, Duanduan
Wang, Changming
Li, Yulong
Ma, Xudong
Tang, Xiaoying
Wu, Jinglong
Deng, Yiming
Zhao, Lun
author_sort Yan, Tianyi
collection PubMed
description Schizophrenia is often considered to be a disconnection syndrome. The abnormal interactions between large-scale functional brain networks result in cognitive and perceptual deficits. The present study investigated event-related functional connectivity networks to compare facial processing in individuals with and without schizophrenia. Faces and tables were presented to participants, and event-related phase synchrony, represented by the phase lag index (PLI), was calculated. In addition, cortical oscillatory dynamics may be useful for understanding the neural mechanisms underlying the disparate cognitive and functional impairments in schizophrenic patients. Therefore, the dynamic graph theoretical networks related to facial processing were compared between individuals with and without schizophrenia. Our results showed that event-related phase synchrony was significantly reduced in distributed networks, and normalized clustering coefficients were significantly increased in schizophrenic patients relative to those of the controls. The present data suggest that schizophrenic patients have specific alterations, indicated by increased local connectivity in gamma oscillations during facial processing.
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spelling pubmed-57398162017-12-29 Increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from EEG data Yan, Tianyi Wang, Wenhui Liu, Tiantian Chen, Duanduan Wang, Changming Li, Yulong Ma, Xudong Tang, Xiaoying Wu, Jinglong Deng, Yiming Zhao, Lun Oncotarget Clinical Research Paper Schizophrenia is often considered to be a disconnection syndrome. The abnormal interactions between large-scale functional brain networks result in cognitive and perceptual deficits. The present study investigated event-related functional connectivity networks to compare facial processing in individuals with and without schizophrenia. Faces and tables were presented to participants, and event-related phase synchrony, represented by the phase lag index (PLI), was calculated. In addition, cortical oscillatory dynamics may be useful for understanding the neural mechanisms underlying the disparate cognitive and functional impairments in schizophrenic patients. Therefore, the dynamic graph theoretical networks related to facial processing were compared between individuals with and without schizophrenia. Our results showed that event-related phase synchrony was significantly reduced in distributed networks, and normalized clustering coefficients were significantly increased in schizophrenic patients relative to those of the controls. The present data suggest that schizophrenic patients have specific alterations, indicated by increased local connectivity in gamma oscillations during facial processing. Impact Journals LLC 2017-09-01 /pmc/articles/PMC5739816/ /pubmed/29291031 http://dx.doi.org/10.18632/oncotarget.20598 Text en Copyright: © 2017 Yan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Yan, Tianyi
Wang, Wenhui
Liu, Tiantian
Chen, Duanduan
Wang, Changming
Li, Yulong
Ma, Xudong
Tang, Xiaoying
Wu, Jinglong
Deng, Yiming
Zhao, Lun
Increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from EEG data
title Increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from EEG data
title_full Increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from EEG data
title_fullStr Increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from EEG data
title_full_unstemmed Increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from EEG data
title_short Increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from EEG data
title_sort increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from eeg data
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739816/
https://www.ncbi.nlm.nih.gov/pubmed/29291031
http://dx.doi.org/10.18632/oncotarget.20598
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