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Primary non-Hodgkin lymphoma of the prostate: a case report

This report is of a 68-year-old male patient with a three-year history of severe, progressive, low urinary tract symptoms (LUTS) with a score of 20 points on the International Symptom Scale. The patient received alpha-1-blocker therapy without adequate response. Transurethral resection of the prosta...

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Autores principales: Martín, Oscar D, Wadskier, Luis Alfredo, Quiroz, Yesica, Bravo, Heilen P, Cacciamani, Giovanni, Umaña, Paola, Medina, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739870/
https://www.ncbi.nlm.nih.gov/pubmed/29290758
http://dx.doi.org/10.3332/ecancer.2017.789
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author Martín, Oscar D
Wadskier, Luis Alfredo
Quiroz, Yesica
Bravo, Heilen P
Cacciamani, Giovanni
Umaña, Paola
Medina, Luis
author_facet Martín, Oscar D
Wadskier, Luis Alfredo
Quiroz, Yesica
Bravo, Heilen P
Cacciamani, Giovanni
Umaña, Paola
Medina, Luis
author_sort Martín, Oscar D
collection PubMed
description This report is of a 68-year-old male patient with a three-year history of severe, progressive, low urinary tract symptoms (LUTS) with a score of 20 points on the International Symptom Scale. The patient received alpha-1-blocker therapy without adequate response. Transurethral resection of the prostate was performed, and the anatomopathological report indicated the presence of a haematolymphoid small-cell neoplasia and glandulostromal prostatic hyperplasia. Posterior immunohistochemistry evaluation reported an extra-nodal marginal zone-B lymphoma non-Hodgkin lymphoma. The patient was followed up for five years by the urology and oncology departments. In the fourth year of follow-up, the patient had B symptoms (fever, night sweats and weight loss). At the same time, laboratory tests showed haemolytic anaemia; then a new bone marrow biopsy was carried out. The histopathological specimen showed six lymphoid aggregates, constituted by a B-cell population with intra-trabecular predominance and reactivity for CD20 and BCL-2. New thoracic and abdominal computed tomographies were performed without any findings suggestive of extra-prostatic spreading. Subsequently, a chemotherapy regimen was started on the patient with the following therapeutic scheme: Rituximab 375 mg/m(2) IV per day, cyclophosphamide 750 mg/m(2) IV per day, Vincristine 1.4 mg/m(2) IV dose per day and Prednisone 40 mg/m(2) on days 1–5 (R-CVP scheme) for 21 days, until he completed six cycles. No signs, symptoms or progression have been recorded.
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spelling pubmed-57398702017-12-29 Primary non-Hodgkin lymphoma of the prostate: a case report Martín, Oscar D Wadskier, Luis Alfredo Quiroz, Yesica Bravo, Heilen P Cacciamani, Giovanni Umaña, Paola Medina, Luis Ecancermedicalscience Case Report This report is of a 68-year-old male patient with a three-year history of severe, progressive, low urinary tract symptoms (LUTS) with a score of 20 points on the International Symptom Scale. The patient received alpha-1-blocker therapy without adequate response. Transurethral resection of the prostate was performed, and the anatomopathological report indicated the presence of a haematolymphoid small-cell neoplasia and glandulostromal prostatic hyperplasia. Posterior immunohistochemistry evaluation reported an extra-nodal marginal zone-B lymphoma non-Hodgkin lymphoma. The patient was followed up for five years by the urology and oncology departments. In the fourth year of follow-up, the patient had B symptoms (fever, night sweats and weight loss). At the same time, laboratory tests showed haemolytic anaemia; then a new bone marrow biopsy was carried out. The histopathological specimen showed six lymphoid aggregates, constituted by a B-cell population with intra-trabecular predominance and reactivity for CD20 and BCL-2. New thoracic and abdominal computed tomographies were performed without any findings suggestive of extra-prostatic spreading. Subsequently, a chemotherapy regimen was started on the patient with the following therapeutic scheme: Rituximab 375 mg/m(2) IV per day, cyclophosphamide 750 mg/m(2) IV per day, Vincristine 1.4 mg/m(2) IV dose per day and Prednisone 40 mg/m(2) on days 1–5 (R-CVP scheme) for 21 days, until he completed six cycles. No signs, symptoms or progression have been recorded. Cancer Intelligence 2017-12-12 /pmc/articles/PMC5739870/ /pubmed/29290758 http://dx.doi.org/10.3332/ecancer.2017.789 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Martín, Oscar D
Wadskier, Luis Alfredo
Quiroz, Yesica
Bravo, Heilen P
Cacciamani, Giovanni
Umaña, Paola
Medina, Luis
Primary non-Hodgkin lymphoma of the prostate: a case report
title Primary non-Hodgkin lymphoma of the prostate: a case report
title_full Primary non-Hodgkin lymphoma of the prostate: a case report
title_fullStr Primary non-Hodgkin lymphoma of the prostate: a case report
title_full_unstemmed Primary non-Hodgkin lymphoma of the prostate: a case report
title_short Primary non-Hodgkin lymphoma of the prostate: a case report
title_sort primary non-hodgkin lymphoma of the prostate: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739870/
https://www.ncbi.nlm.nih.gov/pubmed/29290758
http://dx.doi.org/10.3332/ecancer.2017.789
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