Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles

Vaccines targeting the human papillomavirus (HPV) minor capsid protein L2 are emerging as chemico-physically robust and broadly protective alternatives to the current HPV (L1-VLP) vaccines. We have previously developed a trivalent L2 vaccine prototype exploiting Pyrococcus furiosus thioredoxin (PfTr...

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Detalles Bibliográficos
Autores principales: Spagnoli, Gloria, Pouyanfard, Somayeh, Cavazzini, Davide, Canali, Elena, Maggi, Stefano, Tommasino, Massimo, Bolchi, Angelo, Müller, Martin, Ottonello, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740060/
https://www.ncbi.nlm.nih.gov/pubmed/29269879
http://dx.doi.org/10.1038/s41598-017-18177-1

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