Endosomal binding kinetics of Eps15 and Hrs specifically regulate the degradation of RTKs

Activation of EGF-R and PDGF-R triggers autophosphorylation and the recruitment of Eps15 and Hrs. These two endosomal proteins are important for specific receptor sorting. Hrs is recruiting ubiquitinated receptors to early endosomes to further facilitate degradation through the ESCRT complex. Upon r...

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Detalles Bibliográficos
Autores principales: Haugen, Linda Hofstad, Skjeldal, Frode Miltzow, Bergeland, Trygve, Bakke, Oddmund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740074/
https://www.ncbi.nlm.nih.gov/pubmed/29269784
http://dx.doi.org/10.1038/s41598-017-17320-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740074/
https://www.ncbi.nlm.nih.gov/pubmed/29269784
http://dx.doi.org/10.1038/s41598-017-17320-2

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