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Cryo-EM structure of a licensed DNA replication origin

Eukaryotic origins of replication are licensed upon loading of the MCM helicase motor onto DNA. ATP hydrolysis by MCM is required for loading and the post-catalytic MCM is an inactive double hexamer that encircles duplex DNA. Origin firing depends on MCM engagement of Cdc45 and GINS to form the CMG...

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Detalles Bibliográficos
Autores principales:	Abid Ali, Ferdos, Douglas, Max E., Locke, Julia, Pye, Valerie E., Nans, Andrea, Diffley, John F. X., Costa, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740162/ https://www.ncbi.nlm.nih.gov/pubmed/29269875 http://dx.doi.org/10.1038/s41467-017-02389-0

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