Lateral hypothalamic activity indicates hunger and satiety states in humans

Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader–Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food‐related cues induced an increase in beta/low‐gamma activity. In contrast, recordings during satiety were marked b...

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Detalles Bibliográficos
Autores principales: Talakoub, Omid, Paiva, Raquel R., Milosevic, Matija, Hoexter, Marcelo Q., Franco, Ruth, Alho, Eduardo, Navarro, Jessie, Pereira, José F., Popovic, Milos R., Savage, Cary, Lopes, Antonio C., Alvarenga, Pedro, Damiani, Durval, Teixeira, Manoel J., Miguel, Euripides C., Fonoff, Erich T., Batistuzzo, Marcelo C., Hamani, Clement
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740250/
https://www.ncbi.nlm.nih.gov/pubmed/29296618
http://dx.doi.org/10.1002/acn3.466
Descripción
Sumario:Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader–Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food‐related cues induced an increase in beta/low‐gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha‐frequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued to crave food. This suggests that the pattern of activity in LHA may indicate hunger/satiety states in humans but attest to the complexity of conducting neuromodulation studies in obesity.

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