A framework for exhaustively mapping functional missense variants

Although we now routinely sequence human genomes, we can confidently identify only a fraction of the sequence variants that have a functional impact. Here, we developed a deep mutational scanning framework that produces exhaustive maps for human missense variants by combining random codon mutagenesi...

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Detalles Bibliográficos
Autores principales: Weile, Jochen, Sun, Song, Cote, Atina G, Knapp, Jennifer, Verby, Marta, Mellor, Joseph C, Wu, Yingzhou, Pons, Carles, Wong, Cassandra, van Lieshout, Natascha, Yang, Fan, Tasan, Murat, Tan, Guihong, Yang, Shan, Fowler, Douglas M, Nussbaum, Robert, Bloom, Jesse D, Vidal, Marc, Hill, David E, Aloy, Patrick, Roth, Frederick P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740498/
https://www.ncbi.nlm.nih.gov/pubmed/29269382
http://dx.doi.org/10.15252/msb.20177908

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