Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks

BACKGROUND: Breast cancer (BC) is the most common malignancy in women and has a major heritable component. The risks associated with most rare susceptibility variants are not well estimated. To better characterise the contribution of variants in ATM, CHEK2, PALB2 and XRCC2, we sequenced their coding...

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Detalles Bibliográficos
Autores principales: Decker, Brennan, Allen, Jamie, Luccarini, Craig, Pooley, Karen A, Shah, Mitul, Bolla, Manjeet K, Wang, Qin, Ahmed, Shahana, Baynes, Caroline, Conroy, Don M, Brown, Judith, Luben, Robert, Ostrander, Elaine A, Pharoah, Paul DP, Dunning, Alison M, Easton, Douglas F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Cancer Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740532/
https://www.ncbi.nlm.nih.gov/pubmed/28779002
http://dx.doi.org/10.1136/jmedgenet-2017-104588

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