Oxidized low-density lipoprotein-induced p62/SQSTM1 accumulation in THP-1-derived macrophages promotes IL-18 secretion and cell death

Macrophage autophagy has a protective role in the development of atherosclerosis; however, it turns dysfunctional in advanced lesions with an increase in p62/sequestosome-1 protein. Little is known about the role and significance of p62 accumulation in atherosclerosis. The present study investigated...

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Detalles Bibliográficos
Autores principales: Ning, Haofeng, Liu, Dan, Yu, Xiaochen, Guan, Xiuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740607/
https://www.ncbi.nlm.nih.gov/pubmed/29285070
http://dx.doi.org/10.3892/etm.2017.5221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740607/
https://www.ncbi.nlm.nih.gov/pubmed/29285070
http://dx.doi.org/10.3892/etm.2017.5221

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