Cargando…

Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling

TGF-β/BMP (bone morphogenetic protein) signaling pathways play conserved roles in controlling embryonic development, tissue homeostasis, and stem cell regulation. Inhibitory Smads (I-Smads) have been shown to negatively regulate TGF-β/BMP signaling by primarily targeting the type I receptors for ubi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wenqing, Li, Weini, Zou, Lihui, Ji, Shanming, Li, Chaoyi, Liu, Kehui, Zhang, Guoqiang, Sun, Qinmiao, Xiao, Fei, Chen, Dahua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2017
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740658/ https://www.ncbi.nlm.nih.gov/pubmed/29180412 http://dx.doi.org/10.1073/pnas.1710540114

Ejemplares similares

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
por: Zou, Ming-Li, et al.
Publicado: (2021)

Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors
por: BabuRajendran, Nithya, et al.
Publicado: (2010)

Msk is required for nuclear import of TGF-β/BMP-activated Smads
por: Xu, Lan, et al.
Publicado: (2007)

Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila
por: Ji, Shanming, et al.
Publicado: (2014)

Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis
por: Liao, Peng, et al.
Publicado: (2017)

Spatio-Temporal Distribution of Smads and Role of Smads/TGF-β/BMP-4 in the Regulation of Mouse Bladder Organogenesis
por: Islam, Syed S., et al.
Publicado: (2013)

Correction: Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis
por: Liao, Peng, et al.
Publicado: (2017)

NANOG regulates the proliferation of PCSCs via the TGF-β1/SMAD pathway
por: Liu, Changming, et al.
Publicado: (2020)

Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation
por: Fan, Xiaoqing, et al.
Publicado: (2021)

LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells
por: Kong, Xiaohui, et al.
Publicado: (2022)

Editorial: TGF-β and BMP signaling in cancer
por: Yan, Xiaohua, et al.
Publicado: (2022)

Protein Palmitoylation Regulates Osteoblast Differentiation through BMP-Induced Osterix Expression
por: Leong, Wai Fook, et al.
Publicado: (2009)

BMP-4, TGF-β and Smad3 as Modulators of Synovial Fluid Cells Viability
por: Sousa, Eduardo Branco de, et al.
Publicado: (2021)

Correction: Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation
por: Fan, Xiaoqing, et al.
Publicado: (2021)

Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver
por: Gerjevic, Lisa Nicole, et al.
Publicado: (2012)

KIZ/GM114 Balances the NF-ĸB Signaling by Antagonizing the Association of TRAF2/6 With Their Upstream Adaptors
por: Sun, Jiawei, et al.
Publicado: (2022)

An inhibitory role of NEK6 in TGFβ/Smad signaling pathway
por: Zuo, Jie, et al.
Publicado: (2015)

A protocol for mimicking lipid-mediated phase separation on the membrane using giant unilamellar vesicles
por: Zhu, Yuanxiang, et al.
Publicado: (2022)

Cysteine 70 of Ankyrin-G Is S-Palmitoylated and Is Required for Function of Ankyrin-G in Membrane Domain Assembly
por: He, Meng, et al.
Publicado: (2012)

β-Ecdysterone Enhanced Bone Regeneration Through the BMP-2/SMAD/RUNX2/Osterix Signaling Pathway
por: Yan, Cai-Ping, et al.
Publicado: (2022)

AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells
por: Brunner, Patrizia, et al.
Publicado: (2020)

Massive endocytosis triggered by surface membrane palmitoylation under mitochondrial control in BHK fibroblasts
por: Hilgemann, Donald W, et al.
Publicado: (2013)

Smad1 stabilization and delocalization in response to the blockade of BMP activity
por: Li, Lili, et al.
Publicado: (2013)

Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma
por: Zhang, Yitong, et al.
Publicado: (2021)

Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex
por: Wang, Shijun, et al.
Publicado: (2012)

KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway
por: Xu, Hongyuan, et al.
Publicado: (2022)

Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex
por: Shi, Meng, et al.
Publicado: (2022)

Protein Palmitoylation in Leukocyte Signaling and Function
por: Yang, Xiaoyuan, et al.
Publicado: (2020)

Protein Lipidation by Palmitoylation and Myristoylation in Cancer
por: Fhu, Chee Wai, et al.
Publicado: (2021)

Corrigendum: ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization
por: Liu, Enping, et al.
Publicado: (2021)

ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization
por: Liu, Enping, et al.
Publicado: (2021)

Noggin Overexpression Impairs the Development of Muscles, Tendons, and Aponeurosis in Soft Palates by Disrupting BMP-Smad and Shh-Gli1 Signaling
por: Deng, Jiamin, et al.
Publicado: (2021)

Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation
por: Gao, Yuhua, et al.
Publicado: (2019)

TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling
por: Guca, Ewelina, et al.
Publicado: (2018)

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors
por: Olsen, Oddrun Elise, et al.
Publicado: (2020)

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
por: Zhenye, Li, et al.
Publicado: (2014)

miR‐130a‐3p regulated TGF‐β1‐induced epithelial‐mesenchymal transition depends on SMAD4 in EC‐1 cells
por: Tian, Xiaokang, et al.
Publicado: (2019)

Inhibitory effect of blocking TGF-β/Smad signal on injury-induced fibrosis of corneal endothelium
por: Sumioka, Takayoshi, et al.
Publicado: (2008)

Corrigendum: Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation
por: Gao, Yuhua, et al.
Publicado: (2020)

TGF‐β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling
por: Wang, Qingxuan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8k99nef2313tk9pjhaj7on038m