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Discriminative ability of quality of life measures in multiple sclerosis
BACKGROUND: Though many people with multiple sclerosis (MS) have comorbidities, the use of generic and disease-specific health related quality of life (HRQOL) scales to discriminate the effects of comorbidity has not been established. The utility of these scales to discriminate differences between p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740906/ https://www.ncbi.nlm.nih.gov/pubmed/29268750 http://dx.doi.org/10.1186/s12955-017-0828-0 |
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author | Fiest, Kirsten M. Greenfield, Jamie Metz, Luanne M. Patten, Scott B. Jetté, Nathalie Marrie, Ruth Ann |
author_facet | Fiest, Kirsten M. Greenfield, Jamie Metz, Luanne M. Patten, Scott B. Jetté, Nathalie Marrie, Ruth Ann |
author_sort | Fiest, Kirsten M. |
collection | PubMed |
description | BACKGROUND: Though many people with multiple sclerosis (MS) have comorbidities, the use of generic and disease-specific health related quality of life (HRQOL) scales to discriminate the effects of comorbidity has not been established. The utility of these scales to discriminate differences between persons with varying levels of disability is also unknown. METHODS: Using online questionnaires, a convenience sample of Albertans with MS was recruited between July 2011 and March 2013. Participants completed demographic questions, a validated comorbidity questionnaire, a self-reported disability scale, and the following HRQOL scales: the Short Form (SF)-36, SF-6D, Health Utilities Index-Mark III (HUI-III), and Multiple Sclerosis Quality of Life-54 (MSQOL-54). The ability of each HRQOL scale to distinguish between comorbidity groups was assessed using a one-way analysis of covariance, adjusting for age, sex, disease course, and disability level. RESULTS: Five hundred sixty three participants completed all relevant questionnaires. All HRQOL measures distinguished between persons with or without depression, while none were able to distinguish between participants with or without hypertension, thyroid disease, irritable bowel syndrome, or osteoporosis. The SF-36 physical scale, SF-6D, HUI-III, and MSQOL-54 physical scales were able to distinguish between all disability groups, though the HUI-III was better able to distinguish between individuals with moderate versus severe disability. CONCLUSIONS: Disease-specific measures would discriminate better between those with and without comorbidities than generic-specific measures and the HUI-III would discriminate best between persons with differing severities of disability. Generic or disease-specific measures may be useful in future studies examining the effects of comorbidity in MS and the effects of treatment of comorbidities in MS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12955-017-0828-0) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5740906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57409062018-01-03 Discriminative ability of quality of life measures in multiple sclerosis Fiest, Kirsten M. Greenfield, Jamie Metz, Luanne M. Patten, Scott B. Jetté, Nathalie Marrie, Ruth Ann Health Qual Life Outcomes Research BACKGROUND: Though many people with multiple sclerosis (MS) have comorbidities, the use of generic and disease-specific health related quality of life (HRQOL) scales to discriminate the effects of comorbidity has not been established. The utility of these scales to discriminate differences between persons with varying levels of disability is also unknown. METHODS: Using online questionnaires, a convenience sample of Albertans with MS was recruited between July 2011 and March 2013. Participants completed demographic questions, a validated comorbidity questionnaire, a self-reported disability scale, and the following HRQOL scales: the Short Form (SF)-36, SF-6D, Health Utilities Index-Mark III (HUI-III), and Multiple Sclerosis Quality of Life-54 (MSQOL-54). The ability of each HRQOL scale to distinguish between comorbidity groups was assessed using a one-way analysis of covariance, adjusting for age, sex, disease course, and disability level. RESULTS: Five hundred sixty three participants completed all relevant questionnaires. All HRQOL measures distinguished between persons with or without depression, while none were able to distinguish between participants with or without hypertension, thyroid disease, irritable bowel syndrome, or osteoporosis. The SF-36 physical scale, SF-6D, HUI-III, and MSQOL-54 physical scales were able to distinguish between all disability groups, though the HUI-III was better able to distinguish between individuals with moderate versus severe disability. CONCLUSIONS: Disease-specific measures would discriminate better between those with and without comorbidities than generic-specific measures and the HUI-III would discriminate best between persons with differing severities of disability. Generic or disease-specific measures may be useful in future studies examining the effects of comorbidity in MS and the effects of treatment of comorbidities in MS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12955-017-0828-0) contains supplementary material, which is available to authorized users. BioMed Central 2017-12-21 /pmc/articles/PMC5740906/ /pubmed/29268750 http://dx.doi.org/10.1186/s12955-017-0828-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Fiest, Kirsten M. Greenfield, Jamie Metz, Luanne M. Patten, Scott B. Jetté, Nathalie Marrie, Ruth Ann Discriminative ability of quality of life measures in multiple sclerosis |
title | Discriminative ability of quality of life measures in multiple sclerosis |
title_full | Discriminative ability of quality of life measures in multiple sclerosis |
title_fullStr | Discriminative ability of quality of life measures in multiple sclerosis |
title_full_unstemmed | Discriminative ability of quality of life measures in multiple sclerosis |
title_short | Discriminative ability of quality of life measures in multiple sclerosis |
title_sort | discriminative ability of quality of life measures in multiple sclerosis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740906/ https://www.ncbi.nlm.nih.gov/pubmed/29268750 http://dx.doi.org/10.1186/s12955-017-0828-0 |
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