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Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair

Improper DNA double-strand break (DSB) repair results in complex genomic rearrangements (CGRs) in many cancers and various congenital disorders in humans. Trinucleotide repeat sequences, such as (GAA)(n) repeats in Friedreich's ataxia, (CTG)(n) repeats in myotonic dystrophy, and (CGG)(n) repeat...

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Detalles Bibliográficos
Autores principales:	McGinty, Ryan J., Rubinstein, Rachel G., Neil, Alexander J., Dominska, Margaret, Kiktev, Denis, Petes, Thomas D., Mirkin, Sergei M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741057/ https://www.ncbi.nlm.nih.gov/pubmed/29113982 http://dx.doi.org/10.1101/gr.228148.117

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