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Forced expression of IL-7R promotes CD8 T cell cytotoxicity to self antigen
Cross-presentation of apoptotic cell associated antigens by immature dendritic cells prevents the activation of self reactive CD8 T cells. Tolerized self reactive CD8 T cells down-regulate IL-7R expression on their surface. Whether over-expression of IL-7R can reverse their fate and function has not...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741212/ https://www.ncbi.nlm.nih.gov/pubmed/29272267 http://dx.doi.org/10.1371/journal.pone.0188112 |