Refractory Adult Onset Still’s Disease

It is often a challenge and a dilemma for clinicians encountering patients with pyrexia of unknown origin. Numerous tests performed to determine the underlying cause often give inconclusive results. We present a 52-year-old man with undulating fever for more than 10 months with persistent hyperferri...

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Autores principales: Sulaiman, Wahinuddin, Abdullah, Aris Chandran, Tan Tsen Chuen, Jerome, Baba, Shaffie, Karim, Norain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Rheumatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741270/
https://www.ncbi.nlm.nih.gov/pubmed/29282446
http://dx.doi.org/10.7759/cureus.1802
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author Sulaiman, Wahinuddin
Abdullah, Aris Chandran
Tan Tsen Chuen, Jerome
Baba, Shaffie
Karim, Norain
author_facet Sulaiman, Wahinuddin
Abdullah, Aris Chandran
Tan Tsen Chuen, Jerome
Baba, Shaffie
Karim, Norain
author_sort Sulaiman, Wahinuddin
collection PubMed
description It is often a challenge and a dilemma for clinicians encountering patients with pyrexia of unknown origin. Numerous tests performed to determine the underlying cause often give inconclusive results. We present a 52-year-old man with undulating fever for more than 10 months with persistent hyperferritinaemia, and negative immunological and serological markers. Despite corticosteroids, disease modifying anti-rheumatic agents and immune-modulator therapy, he succumbed to the illness. A diagnosis of refractory Adult onset Still’s disease complicated by haemophagocytic lymphohistiocytosis was made.
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spelling pubmed-57412702017-12-27 Refractory Adult Onset Still’s Disease Sulaiman, Wahinuddin Abdullah, Aris Chandran Tan Tsen Chuen, Jerome Baba, Shaffie Karim, Norain Cureus Rheumatology It is often a challenge and a dilemma for clinicians encountering patients with pyrexia of unknown origin. Numerous tests performed to determine the underlying cause often give inconclusive results. We present a 52-year-old man with undulating fever for more than 10 months with persistent hyperferritinaemia, and negative immunological and serological markers. Despite corticosteroids, disease modifying anti-rheumatic agents and immune-modulator therapy, he succumbed to the illness. A diagnosis of refractory Adult onset Still’s disease complicated by haemophagocytic lymphohistiocytosis was made. Cureus 2017-10-25 /pmc/articles/PMC5741270/ /pubmed/29282446 http://dx.doi.org/10.7759/cureus.1802 Text en Copyright © 2017, Sulaiman et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Rheumatology
Sulaiman, Wahinuddin
Abdullah, Aris Chandran
Tan Tsen Chuen, Jerome
Baba, Shaffie
Karim, Norain
Refractory Adult Onset Still’s Disease
title Refractory Adult Onset Still’s Disease
title_full Refractory Adult Onset Still’s Disease
title_fullStr Refractory Adult Onset Still’s Disease
title_full_unstemmed Refractory Adult Onset Still’s Disease
title_short Refractory Adult Onset Still’s Disease
title_sort refractory adult onset still’s disease
topic Rheumatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741270/
https://www.ncbi.nlm.nih.gov/pubmed/29282446
http://dx.doi.org/10.7759/cureus.1802
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AT abdullaharischandran refractoryadultonsetstillsdisease
AT tantsenchuenjerome refractoryadultonsetstillsdisease
AT babashaffie refractoryadultonsetstillsdisease
AT karimnorain refractoryadultonsetstillsdisease

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