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Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions

Most preclinical pain models rely on short-duration stimulus-evoked hind paw measurements even though chronic pain is usually a day and night experience. Pain is a debilitating condition that influences the sociability and the ability for voluntary tasks, but the relevant behavioral readouts for the...

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Autores principales: Pitzer, Claudia, Kuner, Rohini, Tappe-Theodor, Anke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741310/
https://www.ncbi.nlm.nih.gov/pubmed/29392189
http://dx.doi.org/10.1097/PR9.0000000000000564
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author Pitzer, Claudia
Kuner, Rohini
Tappe-Theodor, Anke
author_facet Pitzer, Claudia
Kuner, Rohini
Tappe-Theodor, Anke
author_sort Pitzer, Claudia
collection PubMed
description Most preclinical pain models rely on short-duration stimulus-evoked hind paw measurements even though chronic pain is usually a day and night experience. Pain is a debilitating condition that influences the sociability and the ability for voluntary tasks, but the relevant behavioral readouts for these aspects are mostly underrepresented in the literature. Moreover, we lack standardization in most behavioral paradigms. Important aspects are herewith the combination and duration of particular behavioral tasks and the effects of social environment. We aimed at thoroughly investigating stimulus-evoked and voluntary behavioral parameters in the Complete Freund's Adjuvant model of unilateral hind paw inflammation in male mice. Moreover, we analyzed the impact of different social housing conditions. We used a portfolio of classical response measurements, detailed gait analysis, using 2 different measuring systems (Dynamic weight bearing and CatWalk), as well as observer-independent voluntary wheel running and homecage monitoring in a longitudinal time frame. The impact of grouped or isolated housing was investigated in all behavioral paradigms. We observed that unilateral hind paw inflammation provoked changes in several behaviors. Among these were wheel running activity and different homecage activity parameters. Stimulus-evoked hypersensitivity lasted much longer than gait abnormalities and decreased voluntary wheel running activity. Similar effects were monitored in both social housing conditions. This is the first longitudinal study providing detailed insights into various voluntary behavioral parameters related to pain in a unilateral inflammatory model. Stimulus-evoked behavioral changes lasted longer than changes in voluntary behavioral parameters, and the social environment hardly affects these changes.
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spelling pubmed-57413102018-02-01 Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions Pitzer, Claudia Kuner, Rohini Tappe-Theodor, Anke Pain Rep Basic Science Most preclinical pain models rely on short-duration stimulus-evoked hind paw measurements even though chronic pain is usually a day and night experience. Pain is a debilitating condition that influences the sociability and the ability for voluntary tasks, but the relevant behavioral readouts for these aspects are mostly underrepresented in the literature. Moreover, we lack standardization in most behavioral paradigms. Important aspects are herewith the combination and duration of particular behavioral tasks and the effects of social environment. We aimed at thoroughly investigating stimulus-evoked and voluntary behavioral parameters in the Complete Freund's Adjuvant model of unilateral hind paw inflammation in male mice. Moreover, we analyzed the impact of different social housing conditions. We used a portfolio of classical response measurements, detailed gait analysis, using 2 different measuring systems (Dynamic weight bearing and CatWalk), as well as observer-independent voluntary wheel running and homecage monitoring in a longitudinal time frame. The impact of grouped or isolated housing was investigated in all behavioral paradigms. We observed that unilateral hind paw inflammation provoked changes in several behaviors. Among these were wheel running activity and different homecage activity parameters. Stimulus-evoked hypersensitivity lasted much longer than gait abnormalities and decreased voluntary wheel running activity. Similar effects were monitored in both social housing conditions. This is the first longitudinal study providing detailed insights into various voluntary behavioral parameters related to pain in a unilateral inflammatory model. Stimulus-evoked behavioral changes lasted longer than changes in voluntary behavioral parameters, and the social environment hardly affects these changes. Wolters Kluwer 2016-08-09 /pmc/articles/PMC5741310/ /pubmed/29392189 http://dx.doi.org/10.1097/PR9.0000000000000564 Text en Copyright © 2016 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. All rights reserved. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic Science
Pitzer, Claudia
Kuner, Rohini
Tappe-Theodor, Anke
Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions
title Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions
title_full Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions
title_fullStr Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions
title_full_unstemmed Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions
title_short Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions
title_sort voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741310/
https://www.ncbi.nlm.nih.gov/pubmed/29392189
http://dx.doi.org/10.1097/PR9.0000000000000564
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