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The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats

BACKGROUND: Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced com...

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Detalles Bibliográficos
Autores principales:	Chakraborty, Manodeep, Ahmed, Mohammed Gulzar, Bhattacharjee, Ananya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741395/ https://www.ncbi.nlm.nih.gov/pubmed/29296562 http://dx.doi.org/10.1016/j.imr.2017.07.006

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