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Quantitative pulmonary blood flow measurement using (15)O-H(2)O PET with and without tissue fraction correction: a comparison study

BACKGROUND: Physiological measures per lung parenchyma, rather than per lung volume, sometimes reflect the disease status. PET images of the lung, which are usually expressed per lung volume, could confound the interpretation of the disease status, especially in cases with a prominent heterogeneity...

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Autores principales: Matsunaga, Keiko, Yanagawa, Masahiro, Otsuka, Tomoyuki, Hirata, Haruhiko, Kijima, Takashi, Kumanogoh, Atsushi, Tomiyama, Noriyuki, Shimosegawa, Eku, Hatazawa, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741573/
https://www.ncbi.nlm.nih.gov/pubmed/29274016
http://dx.doi.org/10.1186/s13550-017-0350-8
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author Matsunaga, Keiko
Yanagawa, Masahiro
Otsuka, Tomoyuki
Hirata, Haruhiko
Kijima, Takashi
Kumanogoh, Atsushi
Tomiyama, Noriyuki
Shimosegawa, Eku
Hatazawa, Jun
author_facet Matsunaga, Keiko
Yanagawa, Masahiro
Otsuka, Tomoyuki
Hirata, Haruhiko
Kijima, Takashi
Kumanogoh, Atsushi
Tomiyama, Noriyuki
Shimosegawa, Eku
Hatazawa, Jun
author_sort Matsunaga, Keiko
collection PubMed
description BACKGROUND: Physiological measures per lung parenchyma, rather than per lung volume, sometimes reflect the disease status. PET images of the lung, which are usually expressed per lung volume, could confound the interpretation of the disease status, especially in cases with a prominent heterogeneity in aeration. The aim of the present study was to develop a method for measuring pulmonary blood flow (PBF) with aeration correction using (15)O-H(2)O PET and to compare the results with those obtained using a conventional method. We obtained the voxel-based tissue fraction (TF) derived from density images converted from transmission images obtained using an external (137)Cs point source. Quantitative PBF values with and without the TF were calculated using (15)O-H(2)O PET to examine contralateral lung tissue in 9 patients with unilateral lung cancer. The heterogeneity in PBF before and after TF correction was then evaluated and compared. As a measure of PBF heterogeneity, we used the skewness and kurtosis of the PBF distribution. RESULTS: The mean PBF of contralateral lung was 1.4 ± 0.3 mL/min per mL of lung. The TF-corrected PBF was 5.0 ± 0.6 mL/min per mL of lung parenchyma. After TF correction, the skewness and kurtosis of the PBF decreased significantly. CONCLUSIONS: The present PBF calculation method using TF correction demonstrated that the normal PBF increased significantly and the PBF distribution became uniform. The proposed TF correction method is a promising technique to account for variations in density when interpreting PBF in PET studies.
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spelling pubmed-57415732018-01-04 Quantitative pulmonary blood flow measurement using (15)O-H(2)O PET with and without tissue fraction correction: a comparison study Matsunaga, Keiko Yanagawa, Masahiro Otsuka, Tomoyuki Hirata, Haruhiko Kijima, Takashi Kumanogoh, Atsushi Tomiyama, Noriyuki Shimosegawa, Eku Hatazawa, Jun EJNMMI Res Original Research BACKGROUND: Physiological measures per lung parenchyma, rather than per lung volume, sometimes reflect the disease status. PET images of the lung, which are usually expressed per lung volume, could confound the interpretation of the disease status, especially in cases with a prominent heterogeneity in aeration. The aim of the present study was to develop a method for measuring pulmonary blood flow (PBF) with aeration correction using (15)O-H(2)O PET and to compare the results with those obtained using a conventional method. We obtained the voxel-based tissue fraction (TF) derived from density images converted from transmission images obtained using an external (137)Cs point source. Quantitative PBF values with and without the TF were calculated using (15)O-H(2)O PET to examine contralateral lung tissue in 9 patients with unilateral lung cancer. The heterogeneity in PBF before and after TF correction was then evaluated and compared. As a measure of PBF heterogeneity, we used the skewness and kurtosis of the PBF distribution. RESULTS: The mean PBF of contralateral lung was 1.4 ± 0.3 mL/min per mL of lung. The TF-corrected PBF was 5.0 ± 0.6 mL/min per mL of lung parenchyma. After TF correction, the skewness and kurtosis of the PBF decreased significantly. CONCLUSIONS: The present PBF calculation method using TF correction demonstrated that the normal PBF increased significantly and the PBF distribution became uniform. The proposed TF correction method is a promising technique to account for variations in density when interpreting PBF in PET studies. Springer Berlin Heidelberg 2017-12-22 /pmc/articles/PMC5741573/ /pubmed/29274016 http://dx.doi.org/10.1186/s13550-017-0350-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Matsunaga, Keiko
Yanagawa, Masahiro
Otsuka, Tomoyuki
Hirata, Haruhiko
Kijima, Takashi
Kumanogoh, Atsushi
Tomiyama, Noriyuki
Shimosegawa, Eku
Hatazawa, Jun
Quantitative pulmonary blood flow measurement using (15)O-H(2)O PET with and without tissue fraction correction: a comparison study
title Quantitative pulmonary blood flow measurement using (15)O-H(2)O PET with and without tissue fraction correction: a comparison study
title_full Quantitative pulmonary blood flow measurement using (15)O-H(2)O PET with and without tissue fraction correction: a comparison study
title_fullStr Quantitative pulmonary blood flow measurement using (15)O-H(2)O PET with and without tissue fraction correction: a comparison study
title_full_unstemmed Quantitative pulmonary blood flow measurement using (15)O-H(2)O PET with and without tissue fraction correction: a comparison study
title_short Quantitative pulmonary blood flow measurement using (15)O-H(2)O PET with and without tissue fraction correction: a comparison study
title_sort quantitative pulmonary blood flow measurement using (15)o-h(2)o pet with and without tissue fraction correction: a comparison study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741573/
https://www.ncbi.nlm.nih.gov/pubmed/29274016
http://dx.doi.org/10.1186/s13550-017-0350-8
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