Mycobacterium tuberculosis Modulates miR-106b-5p to Control Cathepsin S Expression Resulting in Higher Pathogen Survival and Poor T-Cell Activation

The success of tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), relies on the ability to survive in host cells and escape to immune surveillance and activation. We recently demonstrated that Mtb manipulation of host lysosomal cathepsins in macrophages leads to decreased enzymatic activi...

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Detalles Bibliográficos
Autores principales: Pires, David, Bernard, Elliott M., Pombo, João Palma, Carmo, Nuno, Fialho, Catarina, Gutierrez, Maximiliano Gabriel, Bettencourt, Paulo, Anes, Elsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741618/
https://www.ncbi.nlm.nih.gov/pubmed/29326705
http://dx.doi.org/10.3389/fimmu.2017.01819

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