Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1

Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. Unexpectedly, we...

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Detalles Bibliográficos
Autores principales: Pose-Utrilla, Julia, García-Guerra, Lucía, Del Puerto, Ana, Martín, Abraham, Jurado-Arjona, Jerónimo, De León-Reyes, Noelia S., Gamir-Morralla, Andrea, Sebastián-Serrano, Álvaro, García-Gallo, Mónica, Kremer, Leonor, Fielitz, Jens, Ireson, Christofer, Pérez-Álvarez, Mª José, Ferrer, Isidro, Hernández, Félix, Ávila, Jesús, Lasa, Marina, Campanero, Miguel R., Iglesias, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741635/
https://www.ncbi.nlm.nih.gov/pubmed/29273751
http://dx.doi.org/10.1038/s41467-017-02322-5

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