Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Hundreds of non-proteinogenic (np) amino acids (AA) are found in plants and can in principle enter human protein synthesis through foods. While aminoacyl-tRNA synthetase (AARS) editing potentially provides a mechanism to reject np AAs, some have pathological associations. Co-crystal structures show...

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Detalles Bibliográficos
Autores principales: Song, Youngzee, Zhou, Huihao, Vo, My-Nuong, Shi, Yi, Nawaz, Mir Hussain, Vargas-Rodriguez, Oscar, Diedrich, Jolene K., Yates, John R., Kishi, Shuji, Musier-Forsyth, Karin, Schimmel, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741666/
https://www.ncbi.nlm.nih.gov/pubmed/29273753
http://dx.doi.org/10.1038/s41467-017-02201-z

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