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Multiple Cryptic Binding Sites are Necessary for Robust Fibronectin Assembly: An In Silico Study
The mechanism of assembly of the extracellular matrix protein fibronectin (FN) into elastic, insoluble fibrils is still poorly understood. FN fibrillogenesis requires cell-generated forces, which expose cryptic FN-FN binding sites buried in FN Type III domains. The number and location of cryptic bin...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741729/ https://www.ncbi.nlm.nih.gov/pubmed/29273802 http://dx.doi.org/10.1038/s41598-017-18328-4 |