Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

BACKGROUND: Microglia are major players in the pathogenesis of multiple sclerosis (MS) and may play a dual role in disease progression. The activation status of microglia in vivo is highly dynamic and occurs as a continuum, with the pro-inflammatory and anti-inflammatory phenotypes on either end of...

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Detalles Bibliográficos
Autores principales: Beaino, Wissam, Janssen, Bieneke, Kooij, Gijs, van der Pol, Susanne M. A., van Het Hof, B., van Horssen, Jack, Windhorst, Albert D., de Vries, Helga E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741931/
https://www.ncbi.nlm.nih.gov/pubmed/29273052
http://dx.doi.org/10.1186/s12974-017-1034-z

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