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Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidit...

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Autores principales: Jahromi, Mirza Ali Mofazzal, Zangabad, Parham Sahandi, Basri, Seyed Masoud Moosavi, Zangabad, Keyvan Sahandi, Ghamarypour, Ameneh, Aref, Amir R, Karimi, Mahdi, Hamblin, Michael R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742034/
https://www.ncbi.nlm.nih.gov/pubmed/28782570
http://dx.doi.org/10.1016/j.addr.2017.08.001
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author Jahromi, Mirza Ali Mofazzal
Zangabad, Parham Sahandi
Basri, Seyed Masoud Moosavi
Zangabad, Keyvan Sahandi
Ghamarypour, Ameneh
Aref, Amir R
Karimi, Mahdi
Hamblin, Michael R
author_facet Jahromi, Mirza Ali Mofazzal
Zangabad, Parham Sahandi
Basri, Seyed Masoud Moosavi
Zangabad, Keyvan Sahandi
Ghamarypour, Ameneh
Aref, Amir R
Karimi, Mahdi
Hamblin, Michael R
author_sort Jahromi, Mirza Ali Mofazzal
collection PubMed
description According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally employed to inhibit burn infections followed by a burn wound therapy, because systemic antibiotics have problems in reaching the infected site, coupled with increasing microbial drug resistance. Nanotechnology has provided a range of molecular designed nanostructures (NS) that can be used in both therapeutic and diagnostic applications in burns. These NSs can be divided into organic and non-organic (such as polymeric nanoparticles (NPs) and silver NPs, respectively), and many have been designed to display multifunctional activity. The present review covers the physiology of skin, burn classification, burn wound pathogenesis, animal models of burn wound infection, and various topical therapeutic approaches designed to combat infection and stimulate healing. These include biological based approaches (e.g. immune-based antimicrobial molecules, therapeutic microorganisms, antimicrobial agents, etc.), antimicrobial photo- and ultrasound-therapy, as well as nanotechnology-based wound healing approaches as a revolutionizing area. Thus, we focus on organic and non-organic NSs designed to deliver growth factors to burned skin, and scaffolds, dressings, etc. for exogenous stem cells to aid skin regeneration. Eventually, recent breakthroughs and technologies with substantial potentials in tissue regeneration and skin wound therapy (that are as the basis of burn wound therapies) are briefly taken into consideration including 3D-printing, cell-imprinted substrates, nano-architectured surfaces, and novel gene-editing tools such as CRISPR-Cas.
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spelling pubmed-57420342019-01-01 Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing Jahromi, Mirza Ali Mofazzal Zangabad, Parham Sahandi Basri, Seyed Masoud Moosavi Zangabad, Keyvan Sahandi Ghamarypour, Ameneh Aref, Amir R Karimi, Mahdi Hamblin, Michael R Adv Drug Deliv Rev Article According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally employed to inhibit burn infections followed by a burn wound therapy, because systemic antibiotics have problems in reaching the infected site, coupled with increasing microbial drug resistance. Nanotechnology has provided a range of molecular designed nanostructures (NS) that can be used in both therapeutic and diagnostic applications in burns. These NSs can be divided into organic and non-organic (such as polymeric nanoparticles (NPs) and silver NPs, respectively), and many have been designed to display multifunctional activity. The present review covers the physiology of skin, burn classification, burn wound pathogenesis, animal models of burn wound infection, and various topical therapeutic approaches designed to combat infection and stimulate healing. These include biological based approaches (e.g. immune-based antimicrobial molecules, therapeutic microorganisms, antimicrobial agents, etc.), antimicrobial photo- and ultrasound-therapy, as well as nanotechnology-based wound healing approaches as a revolutionizing area. Thus, we focus on organic and non-organic NSs designed to deliver growth factors to burned skin, and scaffolds, dressings, etc. for exogenous stem cells to aid skin regeneration. Eventually, recent breakthroughs and technologies with substantial potentials in tissue regeneration and skin wound therapy (that are as the basis of burn wound therapies) are briefly taken into consideration including 3D-printing, cell-imprinted substrates, nano-architectured surfaces, and novel gene-editing tools such as CRISPR-Cas. 2017-08-04 2018-01-01 /pmc/articles/PMC5742034/ /pubmed/28782570 http://dx.doi.org/10.1016/j.addr.2017.08.001 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This manuscript version is made available under the CC BY-NC-ND 4.0 license.
spellingShingle Article
Jahromi, Mirza Ali Mofazzal
Zangabad, Parham Sahandi
Basri, Seyed Masoud Moosavi
Zangabad, Keyvan Sahandi
Ghamarypour, Ameneh
Aref, Amir R
Karimi, Mahdi
Hamblin, Michael R
Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing
title Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing
title_full Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing
title_fullStr Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing
title_full_unstemmed Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing
title_short Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing
title_sort nanomedicine and advanced technologies for burns: preventing infection and facilitating wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742034/
https://www.ncbi.nlm.nih.gov/pubmed/28782570
http://dx.doi.org/10.1016/j.addr.2017.08.001
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