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Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons
Acetylcholine is a neuromodulator that shapes information processing in different cortical and subcortical areas. Cell type and location specific cholinergic receptor distributions suggest that acetylcholine in macaque striate cortex should boost feed-forward driven activity, while also reducing pop...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742228/ https://www.ncbi.nlm.nih.gov/pubmed/29311843 http://dx.doi.org/10.3389/fncir.2017.00106 |
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author | Herrero, Jose L. Gieselmann, Marc A. Thiele, Alexander |
author_facet | Herrero, Jose L. Gieselmann, Marc A. Thiele, Alexander |
author_sort | Herrero, Jose L. |
collection | PubMed |
description | Acetylcholine is a neuromodulator that shapes information processing in different cortical and subcortical areas. Cell type and location specific cholinergic receptor distributions suggest that acetylcholine in macaque striate cortex should boost feed-forward driven activity, while also reducing population excitability by increasing inhibitory tone. Studies using cholinergic agonists in anesthetized primate V1 have yielded conflicting evidence for such a proposal. Here we investigated how muscarinic or nicotinic receptor blockade affect neuronal excitability and contrast response functions in awake macaque area V1. Muscarinic or nicotinic receptor blockade caused reduced activity for all contrasts tested, without affecting the contrast where neurons reach their half maximal response (c50). The activity reduction upon muscarinic and nicotinic blockade resulted in reduced neuronal contrast sensitivity, as assessed through neurometric functions. In the majority of cells receptor blockade was best described by a response gain model (a multiplicative scaling of responses), indicating that ACh is involved in signal enhancement, not saliency filtering in macaque V1. |
format | Online Article Text |
id | pubmed-5742228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57422282018-01-08 Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons Herrero, Jose L. Gieselmann, Marc A. Thiele, Alexander Front Neural Circuits Neuroscience Acetylcholine is a neuromodulator that shapes information processing in different cortical and subcortical areas. Cell type and location specific cholinergic receptor distributions suggest that acetylcholine in macaque striate cortex should boost feed-forward driven activity, while also reducing population excitability by increasing inhibitory tone. Studies using cholinergic agonists in anesthetized primate V1 have yielded conflicting evidence for such a proposal. Here we investigated how muscarinic or nicotinic receptor blockade affect neuronal excitability and contrast response functions in awake macaque area V1. Muscarinic or nicotinic receptor blockade caused reduced activity for all contrasts tested, without affecting the contrast where neurons reach their half maximal response (c50). The activity reduction upon muscarinic and nicotinic blockade resulted in reduced neuronal contrast sensitivity, as assessed through neurometric functions. In the majority of cells receptor blockade was best described by a response gain model (a multiplicative scaling of responses), indicating that ACh is involved in signal enhancement, not saliency filtering in macaque V1. Frontiers Media S.A. 2017-12-19 /pmc/articles/PMC5742228/ /pubmed/29311843 http://dx.doi.org/10.3389/fncir.2017.00106 Text en Copyright © 2017 Herrero, Gieselmann and Thiele. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Herrero, Jose L. Gieselmann, Marc A. Thiele, Alexander Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons |
title | Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons |
title_full | Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons |
title_fullStr | Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons |
title_full_unstemmed | Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons |
title_short | Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons |
title_sort | muscarinic and nicotinic contribution to contrast sensitivity of macaque area v1 neurons |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742228/ https://www.ncbi.nlm.nih.gov/pubmed/29311843 http://dx.doi.org/10.3389/fncir.2017.00106 |
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