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Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations
The resolution of joint molecules that link recombining sister chromatids is essential for chromosome segregation. Here, we determine the fate of unresolved recombination intermediates that arise in GEN1(-/-) knock-out cells depleted for MUS81, the two nucleases required for resolution. We find that...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742284/ https://www.ncbi.nlm.nih.gov/pubmed/29255170 http://dx.doi.org/10.1038/s41556-017-0011-1 |