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Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading

Evidence for original antigenic sin in spontaneous thyroid autoimmunity is revealed by autoantibody interactions with immunodominant regions on thyroid autoantigens, thyroglobulin (Tg), thyroid peroxidase (TPO), and the thyrotropin receptor (TSHR) A-subunit. In contrast, antibodies induced by immuni...

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Detalles Bibliográficos
Autores principales:	McLachlan, Sandra M., Rapoport, Basil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742354/ https://www.ncbi.nlm.nih.gov/pubmed/29326719 http://dx.doi.org/10.3389/fimmu.2017.01845

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