Atypical Presentation of Radiation-Associated Breast Angiosarcoma: A Case Report and Review of Literature

Patient: Female, 67 Final Diagnosis: Breast angiosarcoma Symptoms: Skin lesion Medication: — Clinical Procedure: Surgery Specialty: Oncology OBJECTIVE: Unusual clinical course BACKGROUND: Radiation-associated breast angiosarcoma is a rare clinical entity that is thought to be increasing in incidence. CASE REPORT: Here we present the case of a 67-year-old female with a history of left breast invasive ductal carcinoma who received breast conserving surgery and radiation therapy eight years ago. She then presented with a painless mild skin discoloration of the left breast that had been present for over one year. Mammograms and ultra-sounds were normal. A punch biopsy and a subsequent excisional biopsy revealed the diagnosis of angiosarcoma. The patient was treated with mastectomy and had no subsequent recurrences. CONCLUSIONS: The long-term clinical surveillance for all patients who receive breast conservation surgery is recommended and a high degree of suspicion should be exercised in view of potential atypical presentations of this disease.