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From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling

Physiologically based kinetic (PBK) models and the virtual cell based assay can be linked to form so called physiologically based dynamic (PBD) models. This study illustrates the development and application of a PBK model for prediction of estragole-induced DNA adduct formation and hepatotoxicity in...

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Detalles Bibliográficos
Autores principales:	Paini, Alicia, Sala Benito, Jose Vicente, Bessems, Jos, Worth, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pergamon Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742636/ https://www.ncbi.nlm.nih.gov/pubmed/28663056 http://dx.doi.org/10.1016/j.tiv.2017.06.015

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