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Emerging role of Hippo signalling pathway in bladder cancer

Bladder cancer (BC) is one of the most common cancers worldwide with a high progression rate and poor prognosis. The Hippo signalling pathway is a conserved pathway that plays a crucial role in cellular proliferation, differentiation and apoptosis. Furthermore, dysregulation and/or malfunction of th...

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Autores principales: Xia, Jianling, Zeng, Ming, Zhu, Hua, Chen, Xiangjian, Weng, Zhiliang, Li, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742740/
https://www.ncbi.nlm.nih.gov/pubmed/28782275
http://dx.doi.org/10.1111/jcmm.13293
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author Xia, Jianling
Zeng, Ming
Zhu, Hua
Chen, Xiangjian
Weng, Zhiliang
Li, Shi
author_facet Xia, Jianling
Zeng, Ming
Zhu, Hua
Chen, Xiangjian
Weng, Zhiliang
Li, Shi
author_sort Xia, Jianling
collection PubMed
description Bladder cancer (BC) is one of the most common cancers worldwide with a high progression rate and poor prognosis. The Hippo signalling pathway is a conserved pathway that plays a crucial role in cellular proliferation, differentiation and apoptosis. Furthermore, dysregulation and/or malfunction of the Hippo pathway is common in various human tumours, including BC. In this review, an overview of the Hippo pathway in BC and other cancers is presented. We focus on recent data regarding the Hippo pathway, its network and the regulation of the downstream co‐effectors YAP1/TAZ. The core components of the Hippo pathway, which induce BC stemness acquisition, metastasis and chemoresistance, will be emphasized. Additional research on the Hippo pathway will advance our understanding of the mechanism of BC as well as the development and progression of other cancers and may be exploited therapeutically.
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spelling pubmed-57427402018-01-04 Emerging role of Hippo signalling pathway in bladder cancer Xia, Jianling Zeng, Ming Zhu, Hua Chen, Xiangjian Weng, Zhiliang Li, Shi J Cell Mol Med Reviews Bladder cancer (BC) is one of the most common cancers worldwide with a high progression rate and poor prognosis. The Hippo signalling pathway is a conserved pathway that plays a crucial role in cellular proliferation, differentiation and apoptosis. Furthermore, dysregulation and/or malfunction of the Hippo pathway is common in various human tumours, including BC. In this review, an overview of the Hippo pathway in BC and other cancers is presented. We focus on recent data regarding the Hippo pathway, its network and the regulation of the downstream co‐effectors YAP1/TAZ. The core components of the Hippo pathway, which induce BC stemness acquisition, metastasis and chemoresistance, will be emphasized. Additional research on the Hippo pathway will advance our understanding of the mechanism of BC as well as the development and progression of other cancers and may be exploited therapeutically. John Wiley and Sons Inc. 2017-08-07 2018-01 /pmc/articles/PMC5742740/ /pubmed/28782275 http://dx.doi.org/10.1111/jcmm.13293 Text en © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Xia, Jianling
Zeng, Ming
Zhu, Hua
Chen, Xiangjian
Weng, Zhiliang
Li, Shi
Emerging role of Hippo signalling pathway in bladder cancer
title Emerging role of Hippo signalling pathway in bladder cancer
title_full Emerging role of Hippo signalling pathway in bladder cancer
title_fullStr Emerging role of Hippo signalling pathway in bladder cancer
title_full_unstemmed Emerging role of Hippo signalling pathway in bladder cancer
title_short Emerging role of Hippo signalling pathway in bladder cancer
title_sort emerging role of hippo signalling pathway in bladder cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742740/
https://www.ncbi.nlm.nih.gov/pubmed/28782275
http://dx.doi.org/10.1111/jcmm.13293
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