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EEG Dynamics of a Go/Nogo Task in Children with ADHD

Background: Studies investigating event-related potential (ERP) evoked in a Cue-Go/NoGo paradigm have shown lower frontal N1, N2 and central P3 in children with attention-deficit/hyperactivity disorder (ADHD) compared to typically developing children (TDC). However, the electroencephalographic (EEG)...

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Autores principales: Baijot, Simon, Cevallos, Carlos, Zarka, David, Leroy, Axelle, Slama, Hichem, Colin, Cecile, Deconinck, Nicolas, Dan, Bernard, Cheron, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742770/
https://www.ncbi.nlm.nih.gov/pubmed/29261133
http://dx.doi.org/10.3390/brainsci7120167
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author Baijot, Simon
Cevallos, Carlos
Zarka, David
Leroy, Axelle
Slama, Hichem
Colin, Cecile
Deconinck, Nicolas
Dan, Bernard
Cheron, Guy
author_facet Baijot, Simon
Cevallos, Carlos
Zarka, David
Leroy, Axelle
Slama, Hichem
Colin, Cecile
Deconinck, Nicolas
Dan, Bernard
Cheron, Guy
author_sort Baijot, Simon
collection PubMed
description Background: Studies investigating event-related potential (ERP) evoked in a Cue-Go/NoGo paradigm have shown lower frontal N1, N2 and central P3 in children with attention-deficit/hyperactivity disorder (ADHD) compared to typically developing children (TDC). However, the electroencephalographic (EEG) dynamics underlying these ERPs remain largely unexplored in ADHD. Methods: We investigate the event-related spectral perturbation and inter-trial coherence linked to the ERP triggered by visual Cue-Go/NoGo stimuli, in 14 children (7 ADHD and 7 TDC) aged 8 to 12 years. Results: Compared to TDC, the EEG dynamics of children with ADHD showed a lower theta-alpha ITC concomitant to lower occipito-parietal P1-N2 and frontal N1-P2 potentials in response to Cue, Go and Nogo stimuli; an upper alpha power preceding lower central Go-P3; a lower theta-alpha power and ITC were coupled to a lower frontal Nogo-N3; a lower low-gamma power overall scalp at 300 ms after Go and Nogo stimuli. Conclusion: These findings suggest impaired ability in children with ADHD to conserve the brain oscillations phase associated with stimulus processing. This physiological trait might serve as a target for therapeutic intervention or be used as monitoring of their effects.
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spelling pubmed-57427702017-12-29 EEG Dynamics of a Go/Nogo Task in Children with ADHD Baijot, Simon Cevallos, Carlos Zarka, David Leroy, Axelle Slama, Hichem Colin, Cecile Deconinck, Nicolas Dan, Bernard Cheron, Guy Brain Sci Article Background: Studies investigating event-related potential (ERP) evoked in a Cue-Go/NoGo paradigm have shown lower frontal N1, N2 and central P3 in children with attention-deficit/hyperactivity disorder (ADHD) compared to typically developing children (TDC). However, the electroencephalographic (EEG) dynamics underlying these ERPs remain largely unexplored in ADHD. Methods: We investigate the event-related spectral perturbation and inter-trial coherence linked to the ERP triggered by visual Cue-Go/NoGo stimuli, in 14 children (7 ADHD and 7 TDC) aged 8 to 12 years. Results: Compared to TDC, the EEG dynamics of children with ADHD showed a lower theta-alpha ITC concomitant to lower occipito-parietal P1-N2 and frontal N1-P2 potentials in response to Cue, Go and Nogo stimuli; an upper alpha power preceding lower central Go-P3; a lower theta-alpha power and ITC were coupled to a lower frontal Nogo-N3; a lower low-gamma power overall scalp at 300 ms after Go and Nogo stimuli. Conclusion: These findings suggest impaired ability in children with ADHD to conserve the brain oscillations phase associated with stimulus processing. This physiological trait might serve as a target for therapeutic intervention or be used as monitoring of their effects. MDPI 2017-12-20 /pmc/articles/PMC5742770/ /pubmed/29261133 http://dx.doi.org/10.3390/brainsci7120167 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baijot, Simon
Cevallos, Carlos
Zarka, David
Leroy, Axelle
Slama, Hichem
Colin, Cecile
Deconinck, Nicolas
Dan, Bernard
Cheron, Guy
EEG Dynamics of a Go/Nogo Task in Children with ADHD
title EEG Dynamics of a Go/Nogo Task in Children with ADHD
title_full EEG Dynamics of a Go/Nogo Task in Children with ADHD
title_fullStr EEG Dynamics of a Go/Nogo Task in Children with ADHD
title_full_unstemmed EEG Dynamics of a Go/Nogo Task in Children with ADHD
title_short EEG Dynamics of a Go/Nogo Task in Children with ADHD
title_sort eeg dynamics of a go/nogo task in children with adhd
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742770/
https://www.ncbi.nlm.nih.gov/pubmed/29261133
http://dx.doi.org/10.3390/brainsci7120167
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