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Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes

Recent evidence has revealed that a change of functional beta cell mass is an essential factor of the pathophysiology of type 2 diabetes (T2DM). Since beta cell dysfunction is not only present in T2DM but also progressively worsens with disease duration, to preserve or recover functional beta cell m...

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Detalles Bibliográficos
Autores principales: Inaishi, Jun, Saisho, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742802/
https://www.ncbi.nlm.nih.gov/pubmed/29483484
http://dx.doi.org/10.3390/jcm6120113
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author Inaishi, Jun
Saisho, Yoshifumi
author_facet Inaishi, Jun
Saisho, Yoshifumi
author_sort Inaishi, Jun
collection PubMed
description Recent evidence has revealed that a change of functional beta cell mass is an essential factor of the pathophysiology of type 2 diabetes (T2DM). Since beta cell dysfunction is not only present in T2DM but also progressively worsens with disease duration, to preserve or recover functional beta cell mass is important in both prevention of the development of T2DM and therapeutic strategies for T2DM. Furthermore, ethnic difference in functional beta cell mass may also need to be taken into account. Recent evidences suggest that Asians have less beta cell functional capacity compared with Caucasians. Preservation or recovery of functional beta cell mass seems to be further emphasized for Asians because of the limited capacity of beta cell. This review summarizes the current knowledge on beta cell dysfunction in T2DM and discusses the similarities and differences in functional beta cell mass between ethnicities in the face of obesity and T2DM.
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spelling pubmed-57428022017-12-29 Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes Inaishi, Jun Saisho, Yoshifumi J Clin Med Perspective Recent evidence has revealed that a change of functional beta cell mass is an essential factor of the pathophysiology of type 2 diabetes (T2DM). Since beta cell dysfunction is not only present in T2DM but also progressively worsens with disease duration, to preserve or recover functional beta cell mass is important in both prevention of the development of T2DM and therapeutic strategies for T2DM. Furthermore, ethnic difference in functional beta cell mass may also need to be taken into account. Recent evidences suggest that Asians have less beta cell functional capacity compared with Caucasians. Preservation or recovery of functional beta cell mass seems to be further emphasized for Asians because of the limited capacity of beta cell. This review summarizes the current knowledge on beta cell dysfunction in T2DM and discusses the similarities and differences in functional beta cell mass between ethnicities in the face of obesity and T2DM. MDPI 2017-11-30 /pmc/articles/PMC5742802/ /pubmed/29483484 http://dx.doi.org/10.3390/jcm6120113 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Inaishi, Jun
Saisho, Yoshifumi
Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes
title Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes
title_full Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes
title_fullStr Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes
title_full_unstemmed Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes
title_short Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes
title_sort ethnic similarities and differences in the relationship between beta cell mass and diabetes
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742802/
https://www.ncbi.nlm.nih.gov/pubmed/29483484
http://dx.doi.org/10.3390/jcm6120113
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