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Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival
Background: Molecular biomarkers have the potential to predict response to the treatment of rectal cancer. In this study, we aimed to evaluate the prognostic and clinicopathological implication of RAD50 (DNA repair protein RAD50 homolog) expression in rectal cancer. Methods: A total of 266 rectal ca...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742811/ https://www.ncbi.nlm.nih.gov/pubmed/29189711 http://dx.doi.org/10.3390/cancers9120163 |
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author | Ho, Vincent Chung, Liping Singh, Amandeep Lea, Vivienne Revoltar, Maxine Lim, Stephanie H. Tut, Thein-Ga Ng, Weng Lee, Mark de Souza, Paul Shin, Joo-Shik Soon Lee, Cheok |
author_facet | Ho, Vincent Chung, Liping Singh, Amandeep Lea, Vivienne Revoltar, Maxine Lim, Stephanie H. Tut, Thein-Ga Ng, Weng Lee, Mark de Souza, Paul Shin, Joo-Shik Soon Lee, Cheok |
author_sort | Ho, Vincent |
collection | PubMed |
description | Background: Molecular biomarkers have the potential to predict response to the treatment of rectal cancer. In this study, we aimed to evaluate the prognostic and clinicopathological implication of RAD50 (DNA repair protein RAD50 homolog) expression in rectal cancer. Methods: A total of 266 rectal cancer patients who underwent surgery and received chemo- and radiotherapy between 2000 and 2011 were involved in the study. Postoperative RAD50 expression was determined by immunohistochemistry in surgical samples (n = 266). Results: Using Kaplan–Meier survival analysis, we found that low RAD50 expression in postoperative samples was associated with worse disease free survival (p = 0.001) and overall survival (p < 0.001) in early stage/low-grade tumors. In a comparison of patients with low vs. high RAD50 expression, we found that low levels of postoperative RAD50 expression in rectal cancer tissues were significantly associated with perineural invasion (p = 0.002). Conclusion: Expression of RAD50 in rectal cancer may serve as a prognostic biomarker for long-term survival of patients with perineural invasion-positive tumors and for potential use in early stage and low-grade rectal cancer assessment. |
format | Online Article Text |
id | pubmed-5742811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57428112017-12-29 Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival Ho, Vincent Chung, Liping Singh, Amandeep Lea, Vivienne Revoltar, Maxine Lim, Stephanie H. Tut, Thein-Ga Ng, Weng Lee, Mark de Souza, Paul Shin, Joo-Shik Soon Lee, Cheok Cancers (Basel) Article Background: Molecular biomarkers have the potential to predict response to the treatment of rectal cancer. In this study, we aimed to evaluate the prognostic and clinicopathological implication of RAD50 (DNA repair protein RAD50 homolog) expression in rectal cancer. Methods: A total of 266 rectal cancer patients who underwent surgery and received chemo- and radiotherapy between 2000 and 2011 were involved in the study. Postoperative RAD50 expression was determined by immunohistochemistry in surgical samples (n = 266). Results: Using Kaplan–Meier survival analysis, we found that low RAD50 expression in postoperative samples was associated with worse disease free survival (p = 0.001) and overall survival (p < 0.001) in early stage/low-grade tumors. In a comparison of patients with low vs. high RAD50 expression, we found that low levels of postoperative RAD50 expression in rectal cancer tissues were significantly associated with perineural invasion (p = 0.002). Conclusion: Expression of RAD50 in rectal cancer may serve as a prognostic biomarker for long-term survival of patients with perineural invasion-positive tumors and for potential use in early stage and low-grade rectal cancer assessment. MDPI 2017-11-30 /pmc/articles/PMC5742811/ /pubmed/29189711 http://dx.doi.org/10.3390/cancers9120163 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ho, Vincent Chung, Liping Singh, Amandeep Lea, Vivienne Revoltar, Maxine Lim, Stephanie H. Tut, Thein-Ga Ng, Weng Lee, Mark de Souza, Paul Shin, Joo-Shik Soon Lee, Cheok Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival |
title | Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival |
title_full | Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival |
title_fullStr | Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival |
title_full_unstemmed | Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival |
title_short | Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival |
title_sort | early postoperative low expression of rad50 in rectal cancer patients associates with disease-free survival |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742811/ https://www.ncbi.nlm.nih.gov/pubmed/29189711 http://dx.doi.org/10.3390/cancers9120163 |
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