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Synchrotron-Based Pencil Beam Scanning Nozzle with an Integrated Mini-Ridge Filter: A Dosimetric Study to Optimize Treatment Delivery

A mini-ridge filter is often used to widen the Bragg peak in the longitudinal direction at low energies but not high energies. To facilitate the clinical use of a mini-ridge filter, we performed a planning study for the feasibility of a mini-ridge filter as an integral part of the synchrotron nozzle...

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Autores principales: Wang, Xianliang, Li, Yupeng, Zhang, Xiaodong, Li, Heng, Miyazaki, Koichi, Fujimoto, Rintaro, Akiyama, Hiroshi, Gillin, Michael T., Poenisch, Falk, Sahoo, Narayan, Grosshans, David, Gunn, Brandon, Frank, Steven Jay, Wang, Pei, Lang, Jinyi, Hou, Qing, Zhu, Xiaorong Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742818/
https://www.ncbi.nlm.nih.gov/pubmed/29236051
http://dx.doi.org/10.3390/cancers9120170
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author Wang, Xianliang
Li, Yupeng
Zhang, Xiaodong
Li, Heng
Miyazaki, Koichi
Fujimoto, Rintaro
Akiyama, Hiroshi
Gillin, Michael T.
Poenisch, Falk
Sahoo, Narayan
Grosshans, David
Gunn, Brandon
Frank, Steven Jay
Wang, Pei
Lang, Jinyi
Hou, Qing
Zhu, Xiaorong Ronald
author_facet Wang, Xianliang
Li, Yupeng
Zhang, Xiaodong
Li, Heng
Miyazaki, Koichi
Fujimoto, Rintaro
Akiyama, Hiroshi
Gillin, Michael T.
Poenisch, Falk
Sahoo, Narayan
Grosshans, David
Gunn, Brandon
Frank, Steven Jay
Wang, Pei
Lang, Jinyi
Hou, Qing
Zhu, Xiaorong Ronald
author_sort Wang, Xianliang
collection PubMed
description A mini-ridge filter is often used to widen the Bragg peak in the longitudinal direction at low energies but not high energies. To facilitate the clinical use of a mini-ridge filter, we performed a planning study for the feasibility of a mini-ridge filter as an integral part of the synchrotron nozzle (IMRF). Dose models with and without IMRF were commissioned in a commercial Treatment planning system (TPS). Dosimetric characteristics in a homogenous water phantom were compared between plans with and without IMRF for a fixed spread-out Bragg peak width of 4 cm with distal ranges varying from 8 to 30 g/cm(2). Six clinical cases were then used to compare the plan quality between plans. The delivery efficiency was also compared between plans in both the phantom and the clinical cases. The Bragg peak width was increased by 0.18 cm at the lowest energy and by only about 0.04 cm at the highest energy. The IMRF increased the spot size (σ) by up to 0.1 cm at the lowest energy and by only 0.02 cm at the highest energy. For the phantom, the IMRF negligibly affected dose at high energies but increased the lateral penumbra by up to 0.12 cm and the distal penumbra by up to 0.06 cm at low energies. For the clinical cases, the IMRF slightly increased dose to the organs at risk. However, the beam delivery time was reduced from 18.5% to 47.1% for the lung, brain, scalp, and head and neck cases, and dose uniformities of target were improved up to 2.9% for these cases owing to the reduced minimum monitor unit effect. In conclusion, integrating a mini-ridge filter into a synchrotron nozzle is feasible for improving treatment efficiency without significantly sacrificing the plan quality.
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spelling pubmed-57428182017-12-29 Synchrotron-Based Pencil Beam Scanning Nozzle with an Integrated Mini-Ridge Filter: A Dosimetric Study to Optimize Treatment Delivery Wang, Xianliang Li, Yupeng Zhang, Xiaodong Li, Heng Miyazaki, Koichi Fujimoto, Rintaro Akiyama, Hiroshi Gillin, Michael T. Poenisch, Falk Sahoo, Narayan Grosshans, David Gunn, Brandon Frank, Steven Jay Wang, Pei Lang, Jinyi Hou, Qing Zhu, Xiaorong Ronald Cancers (Basel) Article A mini-ridge filter is often used to widen the Bragg peak in the longitudinal direction at low energies but not high energies. To facilitate the clinical use of a mini-ridge filter, we performed a planning study for the feasibility of a mini-ridge filter as an integral part of the synchrotron nozzle (IMRF). Dose models with and without IMRF were commissioned in a commercial Treatment planning system (TPS). Dosimetric characteristics in a homogenous water phantom were compared between plans with and without IMRF for a fixed spread-out Bragg peak width of 4 cm with distal ranges varying from 8 to 30 g/cm(2). Six clinical cases were then used to compare the plan quality between plans. The delivery efficiency was also compared between plans in both the phantom and the clinical cases. The Bragg peak width was increased by 0.18 cm at the lowest energy and by only about 0.04 cm at the highest energy. The IMRF increased the spot size (σ) by up to 0.1 cm at the lowest energy and by only 0.02 cm at the highest energy. For the phantom, the IMRF negligibly affected dose at high energies but increased the lateral penumbra by up to 0.12 cm and the distal penumbra by up to 0.06 cm at low energies. For the clinical cases, the IMRF slightly increased dose to the organs at risk. However, the beam delivery time was reduced from 18.5% to 47.1% for the lung, brain, scalp, and head and neck cases, and dose uniformities of target were improved up to 2.9% for these cases owing to the reduced minimum monitor unit effect. In conclusion, integrating a mini-ridge filter into a synchrotron nozzle is feasible for improving treatment efficiency without significantly sacrificing the plan quality. MDPI 2017-12-13 /pmc/articles/PMC5742818/ /pubmed/29236051 http://dx.doi.org/10.3390/cancers9120170 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Xianliang
Li, Yupeng
Zhang, Xiaodong
Li, Heng
Miyazaki, Koichi
Fujimoto, Rintaro
Akiyama, Hiroshi
Gillin, Michael T.
Poenisch, Falk
Sahoo, Narayan
Grosshans, David
Gunn, Brandon
Frank, Steven Jay
Wang, Pei
Lang, Jinyi
Hou, Qing
Zhu, Xiaorong Ronald
Synchrotron-Based Pencil Beam Scanning Nozzle with an Integrated Mini-Ridge Filter: A Dosimetric Study to Optimize Treatment Delivery
title Synchrotron-Based Pencil Beam Scanning Nozzle with an Integrated Mini-Ridge Filter: A Dosimetric Study to Optimize Treatment Delivery
title_full Synchrotron-Based Pencil Beam Scanning Nozzle with an Integrated Mini-Ridge Filter: A Dosimetric Study to Optimize Treatment Delivery
title_fullStr Synchrotron-Based Pencil Beam Scanning Nozzle with an Integrated Mini-Ridge Filter: A Dosimetric Study to Optimize Treatment Delivery
title_full_unstemmed Synchrotron-Based Pencil Beam Scanning Nozzle with an Integrated Mini-Ridge Filter: A Dosimetric Study to Optimize Treatment Delivery
title_short Synchrotron-Based Pencil Beam Scanning Nozzle with an Integrated Mini-Ridge Filter: A Dosimetric Study to Optimize Treatment Delivery
title_sort synchrotron-based pencil beam scanning nozzle with an integrated mini-ridge filter: a dosimetric study to optimize treatment delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742818/
https://www.ncbi.nlm.nih.gov/pubmed/29236051
http://dx.doi.org/10.3390/cancers9120170
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