PRIMA-1 and PRIMA-1(Met) (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies

p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic missense mutations in TP53 or to an excessive degradation of the protein. Accordingly, reactivation of p53 appears a...

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Detalles Bibliográficos
Autores principales: Perdrix, Anne, Najem, Ahmad, Saussez, Sven, Awada, Ahmad, Journe, Fabrice, Ghanem, Ghanem, Krayem, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742820/
https://www.ncbi.nlm.nih.gov/pubmed/29258181
http://dx.doi.org/10.3390/cancers9120172

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