Three New Malyngamides from the Marine Cyanobacterium Moorea producens

Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and...

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Detalles Bibliográficos
Autores principales: Sueyoshi, Kosuke, Yamano, Aki, Ozaki, Kaori, Sumimoto, Shimpei, Iwasaki, Arihiro, Suenaga, Kiyotake, Teruya, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742827/
https://www.ncbi.nlm.nih.gov/pubmed/29186048
http://dx.doi.org/10.3390/md15120367
Descripción
Sumario:Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK).

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