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A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213

A previously unreported dihydrochromone dimer, paecilin E (1), was isolated, together with eleven known compounds: β-sitostenone, ergosta-4,6,8 (14), 22-tetraen-3-one, cyathisterone, byssochlamic acid, dehydromevalonic acid lactone, chevalone B, aszonalenin, dankasterone A (2), helvolic acid, secalo...

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Autores principales: Kumla, Decha, Shine Aung, Tin, Buttachon, Suradet, Dethoup, Tida, Gales, Luís, Pereira, José A., Inácio, Ângela, Costa, Paulo M., Lee, Michael, Sekeroglu, Nazim, Silva, Artur M. S., Pinto, Madalena M. M., Kijjoa, Anake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742835/
https://www.ncbi.nlm.nih.gov/pubmed/29194412
http://dx.doi.org/10.3390/md15120375
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author Kumla, Decha
Shine Aung, Tin
Buttachon, Suradet
Dethoup, Tida
Gales, Luís
Pereira, José A.
Inácio, Ângela
Costa, Paulo M.
Lee, Michael
Sekeroglu, Nazim
Silva, Artur M. S.
Pinto, Madalena M. M.
Kijjoa, Anake
author_facet Kumla, Decha
Shine Aung, Tin
Buttachon, Suradet
Dethoup, Tida
Gales, Luís
Pereira, José A.
Inácio, Ângela
Costa, Paulo M.
Lee, Michael
Sekeroglu, Nazim
Silva, Artur M. S.
Pinto, Madalena M. M.
Kijjoa, Anake
author_sort Kumla, Decha
collection PubMed
description A previously unreported dihydrochromone dimer, paecilin E (1), was isolated, together with eleven known compounds: β-sitostenone, ergosta-4,6,8 (14), 22-tetraen-3-one, cyathisterone, byssochlamic acid, dehydromevalonic acid lactone, chevalone B, aszonalenin, dankasterone A (2), helvolic acid, secalonic acid A and fellutanine A, from the culture filtrate extract of the marine sponge-associated fungus Neosartorya fennelliae KUFA 0811. Nine previously reported metabolites, including a chromanol derivative (3), (3β, 5α, 22E), 3,5-dihydroxyergosta-7,22-dien-6-one (4), byssochlamic acid, hopan-3β,22-diol, chevalone C, sartorypyrone B, helvolic acid, lumichrome and the alkaloid harmane were isolated from the culture of the marine-sponge associated fungus Neosartorya tsunodae KUFC 9213. Paecilin E (1), dankasterone A (2), a chromanol derivative (3), (3β, 5α, 22E)-3,5-dihydroxyergosta-7,22-dien-6-one (4), hopan-3β,22-diol (5), lumichrome (6), and harmane (7) were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. While paecilin E (1) was active against S. aureus ATCC 29213 and E. faecalis ATCC 29212, dankastetrone A (2) was only effective against E. faecalis ATCC 29212 and the multidrug-resistant VRE E. faecalis A5/102. Both compounds neither inhibit biofilm mass production in any of the strains at the concentrations tested nor exhibit synergistic association with antibiotics.
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spelling pubmed-57428352017-12-29 A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213 Kumla, Decha Shine Aung, Tin Buttachon, Suradet Dethoup, Tida Gales, Luís Pereira, José A. Inácio, Ângela Costa, Paulo M. Lee, Michael Sekeroglu, Nazim Silva, Artur M. S. Pinto, Madalena M. M. Kijjoa, Anake Mar Drugs Article A previously unreported dihydrochromone dimer, paecilin E (1), was isolated, together with eleven known compounds: β-sitostenone, ergosta-4,6,8 (14), 22-tetraen-3-one, cyathisterone, byssochlamic acid, dehydromevalonic acid lactone, chevalone B, aszonalenin, dankasterone A (2), helvolic acid, secalonic acid A and fellutanine A, from the culture filtrate extract of the marine sponge-associated fungus Neosartorya fennelliae KUFA 0811. Nine previously reported metabolites, including a chromanol derivative (3), (3β, 5α, 22E), 3,5-dihydroxyergosta-7,22-dien-6-one (4), byssochlamic acid, hopan-3β,22-diol, chevalone C, sartorypyrone B, helvolic acid, lumichrome and the alkaloid harmane were isolated from the culture of the marine-sponge associated fungus Neosartorya tsunodae KUFC 9213. Paecilin E (1), dankasterone A (2), a chromanol derivative (3), (3β, 5α, 22E)-3,5-dihydroxyergosta-7,22-dien-6-one (4), hopan-3β,22-diol (5), lumichrome (6), and harmane (7) were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. While paecilin E (1) was active against S. aureus ATCC 29213 and E. faecalis ATCC 29212, dankastetrone A (2) was only effective against E. faecalis ATCC 29212 and the multidrug-resistant VRE E. faecalis A5/102. Both compounds neither inhibit biofilm mass production in any of the strains at the concentrations tested nor exhibit synergistic association with antibiotics. MDPI 2017-12-01 /pmc/articles/PMC5742835/ /pubmed/29194412 http://dx.doi.org/10.3390/md15120375 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kumla, Decha
Shine Aung, Tin
Buttachon, Suradet
Dethoup, Tida
Gales, Luís
Pereira, José A.
Inácio, Ângela
Costa, Paulo M.
Lee, Michael
Sekeroglu, Nazim
Silva, Artur M. S.
Pinto, Madalena M. M.
Kijjoa, Anake
A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213
title A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213
title_full A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213
title_fullStr A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213
title_full_unstemmed A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213
title_short A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213
title_sort new dihydrochromone dimer and other secondary metabolites from cultures of the marine sponge-associated fungi neosartorya fennelliae kufa 0811 and neosartorya tsunodae kufc 9213
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742835/
https://www.ncbi.nlm.nih.gov/pubmed/29194412
http://dx.doi.org/10.3390/md15120375
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