Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia

Three new sulfated steroidal glycosides (3–5), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometr...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Yeon-Ju, Han, Saem, Kim, Su Hyun, Lee, Hyi-Seung, Shin, Hee Jae, Lee, Jong Seok, Lee, Jihoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742839/
https://www.ncbi.nlm.nih.gov/pubmed/29207558
http://dx.doi.org/10.3390/md15120379
_version_ 1783288464347758592
author Lee, Yeon-Ju
Han, Saem
Kim, Su Hyun
Lee, Hyi-Seung
Shin, Hee Jae
Lee, Jong Seok
Lee, Jihoon
author_facet Lee, Yeon-Ju
Han, Saem
Kim, Su Hyun
Lee, Hyi-Seung
Shin, Hee Jae
Lee, Jong Seok
Lee, Jihoon
author_sort Lee, Yeon-Ju
collection PubMed
description Three new sulfated steroidal glycosides (3–5), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI(50) values down to 0.49 μM) against the K562 human leukemia cell line.
format Online
Article
Text
id pubmed-5742839
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-57428392017-12-29 Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia Lee, Yeon-Ju Han, Saem Kim, Su Hyun Lee, Hyi-Seung Shin, Hee Jae Lee, Jong Seok Lee, Jihoon Mar Drugs Article Three new sulfated steroidal glycosides (3–5), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI(50) values down to 0.49 μM) against the K562 human leukemia cell line. MDPI 2017-12-04 /pmc/articles/PMC5742839/ /pubmed/29207558 http://dx.doi.org/10.3390/md15120379 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Yeon-Ju
Han, Saem
Kim, Su Hyun
Lee, Hyi-Seung
Shin, Hee Jae
Lee, Jong Seok
Lee, Jihoon
Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia
title Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia
title_full Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia
title_fullStr Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia
title_full_unstemmed Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia
title_short Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia
title_sort three new cytotoxic steroidal glycosides isolated from conus pulicarius collected in kosrae, micronesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742839/
https://www.ncbi.nlm.nih.gov/pubmed/29207558
http://dx.doi.org/10.3390/md15120379
work_keys_str_mv AT leeyeonju threenewcytotoxicsteroidalglycosidesisolatedfromconuspulicariuscollectedinkosraemicronesia
AT hansaem threenewcytotoxicsteroidalglycosidesisolatedfromconuspulicariuscollectedinkosraemicronesia
AT kimsuhyun threenewcytotoxicsteroidalglycosidesisolatedfromconuspulicariuscollectedinkosraemicronesia
AT leehyiseung threenewcytotoxicsteroidalglycosidesisolatedfromconuspulicariuscollectedinkosraemicronesia
AT shinheejae threenewcytotoxicsteroidalglycosidesisolatedfromconuspulicariuscollectedinkosraemicronesia
AT leejongseok threenewcytotoxicsteroidalglycosidesisolatedfromconuspulicariuscollectedinkosraemicronesia
AT leejihoon threenewcytotoxicsteroidalglycosidesisolatedfromconuspulicariuscollectedinkosraemicronesia

Ejemplares similares