Cargando…
Small Intestinal Bacterial Overgrowth Affects the Responsiveness to Colchicine in Familial Mediterranean Fever
OBJECTIVE: Familial Mediterranean fever (FMF) is an autosomal recessive disease due to a MEFV gene mutation. Since Helicobacter pylori infection has been described to increase the severity and frequency of FMF attacks, we evaluate if overgrowth of small intestinal bacterial (SIBO), associated with a...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742903/ https://www.ncbi.nlm.nih.gov/pubmed/29379228 http://dx.doi.org/10.1155/2017/7461426 |
_version_ | 1783288476461957120 |
---|---|
author | Verrecchia, E. Sicignano, L. L. La Regina, M. Nucera, G. Patisso, I. Cerrito, L. Montalto, M. Gasbarrini, A. Manna, R. |
author_facet | Verrecchia, E. Sicignano, L. L. La Regina, M. Nucera, G. Patisso, I. Cerrito, L. Montalto, M. Gasbarrini, A. Manna, R. |
author_sort | Verrecchia, E. |
collection | PubMed |
description | OBJECTIVE: Familial Mediterranean fever (FMF) is an autosomal recessive disease due to a MEFV gene mutation. Since Helicobacter pylori infection has been described to increase the severity and frequency of FMF attacks, we evaluate if overgrowth of small intestinal bacterial (SIBO), associated with a release of bacterial products, can affect the response to colchicine in FMF patients poorly responsive to colchicine. METHODS: We revised our Periodic Fever Centre database to detect FMF patients who were poorly responsive to colchicine, without a well-defined cause of drug resistance. They were evaluated for SIBO presence, then treated with decontamination therapy. RESULTS: Among 223 FMF patients, 49 subjects show colchicine resistance, and no other known causes of colchicine unresponsiveness has been found in 25 patients. All 25 patients underwent glucose breath test; 20 (80%) of them were positive, thus affected by SIBO. After a successful decontamination treatment, 11 patients (55%) did not show FMF attacks during the following three months (p < 0.01), while 9 of them revealed a significant reduction of the number of attacks compared to three months before (p < 0.01). CONCLUSION: The SIBO eradication improves laboratory and clinical features of FMF patients. Thus, patients with unresponsiveness to colchicine treatment should be investigated for SIBO. |
format | Online Article Text |
id | pubmed-5742903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-57429032018-01-29 Small Intestinal Bacterial Overgrowth Affects the Responsiveness to Colchicine in Familial Mediterranean Fever Verrecchia, E. Sicignano, L. L. La Regina, M. Nucera, G. Patisso, I. Cerrito, L. Montalto, M. Gasbarrini, A. Manna, R. Mediators Inflamm Research Article OBJECTIVE: Familial Mediterranean fever (FMF) is an autosomal recessive disease due to a MEFV gene mutation. Since Helicobacter pylori infection has been described to increase the severity and frequency of FMF attacks, we evaluate if overgrowth of small intestinal bacterial (SIBO), associated with a release of bacterial products, can affect the response to colchicine in FMF patients poorly responsive to colchicine. METHODS: We revised our Periodic Fever Centre database to detect FMF patients who were poorly responsive to colchicine, without a well-defined cause of drug resistance. They were evaluated for SIBO presence, then treated with decontamination therapy. RESULTS: Among 223 FMF patients, 49 subjects show colchicine resistance, and no other known causes of colchicine unresponsiveness has been found in 25 patients. All 25 patients underwent glucose breath test; 20 (80%) of them were positive, thus affected by SIBO. After a successful decontamination treatment, 11 patients (55%) did not show FMF attacks during the following three months (p < 0.01), while 9 of them revealed a significant reduction of the number of attacks compared to three months before (p < 0.01). CONCLUSION: The SIBO eradication improves laboratory and clinical features of FMF patients. Thus, patients with unresponsiveness to colchicine treatment should be investigated for SIBO. Hindawi 2017 2017-12-12 /pmc/articles/PMC5742903/ /pubmed/29379228 http://dx.doi.org/10.1155/2017/7461426 Text en Copyright © 2017 E. Verrecchia et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Verrecchia, E. Sicignano, L. L. La Regina, M. Nucera, G. Patisso, I. Cerrito, L. Montalto, M. Gasbarrini, A. Manna, R. Small Intestinal Bacterial Overgrowth Affects the Responsiveness to Colchicine in Familial Mediterranean Fever |
title | Small Intestinal Bacterial Overgrowth Affects the Responsiveness to Colchicine in Familial Mediterranean Fever |
title_full | Small Intestinal Bacterial Overgrowth Affects the Responsiveness to Colchicine in Familial Mediterranean Fever |
title_fullStr | Small Intestinal Bacterial Overgrowth Affects the Responsiveness to Colchicine in Familial Mediterranean Fever |
title_full_unstemmed | Small Intestinal Bacterial Overgrowth Affects the Responsiveness to Colchicine in Familial Mediterranean Fever |
title_short | Small Intestinal Bacterial Overgrowth Affects the Responsiveness to Colchicine in Familial Mediterranean Fever |
title_sort | small intestinal bacterial overgrowth affects the responsiveness to colchicine in familial mediterranean fever |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742903/ https://www.ncbi.nlm.nih.gov/pubmed/29379228 http://dx.doi.org/10.1155/2017/7461426 |
work_keys_str_mv | AT verrecchiae smallintestinalbacterialovergrowthaffectstheresponsivenesstocolchicineinfamilialmediterraneanfever AT sicignanoll smallintestinalbacterialovergrowthaffectstheresponsivenesstocolchicineinfamilialmediterraneanfever AT lareginam smallintestinalbacterialovergrowthaffectstheresponsivenesstocolchicineinfamilialmediterraneanfever AT nucerag smallintestinalbacterialovergrowthaffectstheresponsivenesstocolchicineinfamilialmediterraneanfever AT patissoi smallintestinalbacterialovergrowthaffectstheresponsivenesstocolchicineinfamilialmediterraneanfever AT cerritol smallintestinalbacterialovergrowthaffectstheresponsivenesstocolchicineinfamilialmediterraneanfever AT montaltom smallintestinalbacterialovergrowthaffectstheresponsivenesstocolchicineinfamilialmediterraneanfever AT gasbarrinia smallintestinalbacterialovergrowthaffectstheresponsivenesstocolchicineinfamilialmediterraneanfever AT mannar smallintestinalbacterialovergrowthaffectstheresponsivenesstocolchicineinfamilialmediterraneanfever |