Distinct Rab7-related Endosomal–Autophagic–Lysosomal Dysregulation Observed in Cortex and Hippocampus in APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease

BACKGROUND: Amyloid-β deposition and accumulation of autophagic vacuoles are pathologic features of Alzheimer's disease (AD). Dysregulation of the endosomal–autophagic–lysosomal (EAL) pathway, which impairs amyloid precursor protein processing, is one of the earliest changes in AD. However, the...

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Detalles Bibliográficos
Autores principales: Ba, Li, Chen, Xiao-Hua, Chen, Yan-Lin, Nie, Qing, Li, Zhi-Jun, Ding, Feng-Fei, Zhang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742922/
https://www.ncbi.nlm.nih.gov/pubmed/29237927
http://dx.doi.org/10.4103/0366-6999.220311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742922/
https://www.ncbi.nlm.nih.gov/pubmed/29237927
http://dx.doi.org/10.4103/0366-6999.220311

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