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Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis
AIM: To investigate the impact of cigarette smoking on the recurrence rate and recurrence-free survival in patients with hyperlipidemic acute pancreatitis (HLAP). METHODS: A total of 863 patients were admitted to our hospital for acute pancreatitis (AP) from January 2013 to March 2016, of whom 88 di...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743509/ https://www.ncbi.nlm.nih.gov/pubmed/29307998 http://dx.doi.org/10.3748/wjg.v23.i47.8387 |
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author | Xiang, Jun-Xi Hu, Liang-Shuo Liu, Peng Tian, Bo-Yan Su, Qing Ji, Yi-Chun Zhang, Xu-Feng Liu, Xue-Min Wu, Zheng Lv, Yi |
author_facet | Xiang, Jun-Xi Hu, Liang-Shuo Liu, Peng Tian, Bo-Yan Su, Qing Ji, Yi-Chun Zhang, Xu-Feng Liu, Xue-Min Wu, Zheng Lv, Yi |
author_sort | Xiang, Jun-Xi |
collection | PubMed |
description | AIM: To investigate the impact of cigarette smoking on the recurrence rate and recurrence-free survival in patients with hyperlipidemic acute pancreatitis (HLAP). METHODS: A total of 863 patients were admitted to our hospital for acute pancreatitis (AP) from January 2013 to March 2016, of whom 88 diagnosed with HLAP were enrolled in this retrospective study. Demographic data, medical history, previous episodes of pancreatitis, consumption of alcohol and cigarettes, as well as biochemical and hematological data were carefully recorded for univariate and multivariate analyses. During follow-up, the information on current smoking status and recurrent AP was gathered. Recurrence-free survival (RFS) was calculated using the Kaplan-Meier method, and the differences between groups were compared using the log-rank test. RESULTS: No significant differences were observed between the three groups in age or medical history of hyperlipidemia, fatty liver, diabetes mellitus, hypertension, or AP. The current smokers had a remarkably higher recurrence rate and a greater incidence of repeated episodes of AP (50.0% and 77.8%, respectively) than non-smokers (9.8% and 39.0%), and these two percentages were reduced to 9.1% and 36.4% for patients who gave up smoking. The median follow-up time was 13.5 mo and HLAP recurred after hospital discharge in 23 (26.1%) patients. Multivariate analysis identified current smoking (HR = 6.3, P = 0.020) as an independent risk factor contributing to HLAP recurrence. Current smokers had significantly worse RFS than non-smokers (23 mo vs 42 mo), but no significant difference was documented between ex-smokers (34 mo) and non-smokers. The RFS was not significantly different between light and heavy smokers. CONCLUSION: Smoking is associated with worse RFS and an increased rate of HLAP recurrence. Continued smoking correlates with a compromised survival and smoking cessation should be recommended. |
format | Online Article Text |
id | pubmed-5743509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-57435092018-01-05 Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis Xiang, Jun-Xi Hu, Liang-Shuo Liu, Peng Tian, Bo-Yan Su, Qing Ji, Yi-Chun Zhang, Xu-Feng Liu, Xue-Min Wu, Zheng Lv, Yi World J Gastroenterol Retrospective Study AIM: To investigate the impact of cigarette smoking on the recurrence rate and recurrence-free survival in patients with hyperlipidemic acute pancreatitis (HLAP). METHODS: A total of 863 patients were admitted to our hospital for acute pancreatitis (AP) from January 2013 to March 2016, of whom 88 diagnosed with HLAP were enrolled in this retrospective study. Demographic data, medical history, previous episodes of pancreatitis, consumption of alcohol and cigarettes, as well as biochemical and hematological data were carefully recorded for univariate and multivariate analyses. During follow-up, the information on current smoking status and recurrent AP was gathered. Recurrence-free survival (RFS) was calculated using the Kaplan-Meier method, and the differences between groups were compared using the log-rank test. RESULTS: No significant differences were observed between the three groups in age or medical history of hyperlipidemia, fatty liver, diabetes mellitus, hypertension, or AP. The current smokers had a remarkably higher recurrence rate and a greater incidence of repeated episodes of AP (50.0% and 77.8%, respectively) than non-smokers (9.8% and 39.0%), and these two percentages were reduced to 9.1% and 36.4% for patients who gave up smoking. The median follow-up time was 13.5 mo and HLAP recurred after hospital discharge in 23 (26.1%) patients. Multivariate analysis identified current smoking (HR = 6.3, P = 0.020) as an independent risk factor contributing to HLAP recurrence. Current smokers had significantly worse RFS than non-smokers (23 mo vs 42 mo), but no significant difference was documented between ex-smokers (34 mo) and non-smokers. The RFS was not significantly different between light and heavy smokers. CONCLUSION: Smoking is associated with worse RFS and an increased rate of HLAP recurrence. Continued smoking correlates with a compromised survival and smoking cessation should be recommended. Baishideng Publishing Group Inc 2017-12-21 2017-12-21 /pmc/articles/PMC5743509/ /pubmed/29307998 http://dx.doi.org/10.3748/wjg.v23.i47.8387 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Retrospective Study Xiang, Jun-Xi Hu, Liang-Shuo Liu, Peng Tian, Bo-Yan Su, Qing Ji, Yi-Chun Zhang, Xu-Feng Liu, Xue-Min Wu, Zheng Lv, Yi Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis |
title | Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis |
title_full | Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis |
title_fullStr | Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis |
title_full_unstemmed | Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis |
title_short | Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis |
title_sort | impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743509/ https://www.ncbi.nlm.nih.gov/pubmed/29307998 http://dx.doi.org/10.3748/wjg.v23.i47.8387 |
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