A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway

Rationale: Monoclonal antibodies (mAbs) mostly targeting extracellular or cell surface molecules have been widely used in the treatment of various diseases. However, mAbs cannot pass through the cell membrane as efficiently as small compounds, thus limiting their use against intracellular targets. M...

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Detalles Bibliográficos
Autores principales: Zhang, Jun-Fang, Xiong, Hua-Long, Cao, Jia-Li, Wang, Shao-Juan, Guo, Xue-Ran, Lin, Bi-Yun, Zhang, Ying, Zhao, Jing-Hua, Wang, Ying-Bin, Zhang, Tian-Ying, Yuan, Quan, Zhang, Jun, Xia, Ning-Shao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743566/
https://www.ncbi.nlm.nih.gov/pubmed/29290826
http://dx.doi.org/10.7150/thno.20047

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