Cargando…

Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms in vitro and in vivo

Increasing evidences indicate that shikonin can suppress the tumor growth. However, the mechanisms remain elusive. In the present study, we investigated the effects and mechanisms of shikonin against esophageal cancer. The expression of hypoxia inducible factor 1α (HIF1α) and pyruvate kinase M2 (PKM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Jian-Cai, Zhao, Jia, Long, Feng, Chen, Jian-ye, Mu, Bo, Jiang, Zhen, Ren, Yonggan, Yang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743709/ https://www.ncbi.nlm.nih.gov/pubmed/29290767 http://dx.doi.org/10.7150/jca.21224

Ejemplares similares

Shikonin potentiates the effect of arsenic trioxide against human hepatocellular carcinoma in vitro and in vivo
por: Song, Jingjing, et al.
Publicado: (2016)

Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo
por: Tang, Jian-Cai, et al.
Publicado: (2017)

Preparation, cellular uptake and angiogenic suppression of shikonin-containing liposomes in vitro and in vivo
por: Xia, Hongmei, et al.
Publicado: (2013)

Shikonin potentiates paclitaxel antitumor efficacy in esophageal cancer cells via the apoptotic pathway
por: Du, Wenzhen, et al.
Publicado: (2019)

Effect of Shikonin Against Candida albicans Biofilms
por: Yan, Yu, et al.
Publicado: (2019)

Antiviral activity of shikonin ester derivative PMM-034 against enterovirus 71 in vitro
por: Zhang, Y., et al.
Publicado: (2017)

The anti-leukemia activity and mechanisms of shikonin: a mini review
por: Dong, Han, et al.
Publicado: (2023)

In Vitro Induction of Erythrocyte Phosphatidylserine Translocation by the Natural Naphthoquinone Shikonin
por: Lupescu, Adrian, et al.
Publicado: (2014)

Anticancer Efficacy of Targeted Shikonin Liposomes Modified with RGD in Breast Cancer Cells
por: Wen, Xianchun, et al.
Publicado: (2018)

Effects of shikonin on the development of ovarian follicles and female germline stem cells
por: Ma, Shu-Xin, et al.
Publicado: (2021)

In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus
por: Su, Bo, et al.
Publicado: (2023)

The Effects and Mechanisms by which Saikosaponin-D Enhances the Sensitivity of Human Non-small Cell Lung Cancer Cells to Gefitinib
por: Tang, Jian-cai, et al.
Publicado: (2019)

Sensitizing the Therapeutic Efficacy of Taxol with Shikonin in Human Breast Cancer Cells
por: Li, Wenjuan, et al.
Publicado: (2014)

Exploring the efficacy of tumor electric field therapy against glioblastoma: An in vivo and in vitro study
por: Wu, Hao, et al.
Publicado: (2021)

Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo
por: Lin, Hong-Yan, et al.
Publicado: (2020)

Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS
por: Lan, Tian, et al.
Publicado: (2021)

Evaluation of radical scavenging properties of shikonin
por: Yoshida, Lucia S., et al.
Publicado: (2014)

Promising Nanomedicines of Shikonin for Cancer Therapy
por: Yan, Chunmei, et al.
Publicado: (2023)

Natural Compound Shikonin Is a Novel PAK1 Inhibitor and Enhances Efficacy of Chemotherapy against Pancreatic Cancer Cells
por: Ji, Wenjing, et al.
Publicado: (2022)

The Mechanism Underlying the Antibacterial Activity of Shikonin against Methicillin-Resistant Staphylococcus aureus
por: Lee, Young-Seob, et al.
Publicado: (2015)

Integrative analysis of the shikonin metabolic network identifies new gene connections and reveals evolutionary insight into shikonin biosynthesis
por: Suttiyut, Thiti, et al.
Publicado: (2022)

Shikonin inhibits cancer cell cycling by targeting Cdc25s
por: Zhang, Shoude, et al.
Publicado: (2019)

Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
por: Liang, Wenquan, et al.
Publicado: (2017)

Inhibition of the STAT3 Signaling Pathway Contributes to the Anti-Melanoma Activities of Shikonin
por: Cao, Hui-Hui, et al.
Publicado: (2020)

Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES
por: Chen, Hui-Ming, et al.
Publicado: (2012)

Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation
por: Li, Wenjuan, et al.
Publicado: (2015)

Endogenous nitric oxide accumulation is involved in the antifungal activity of Shikonin against Candida albicans
por: Liao, Zebin, et al.
Publicado: (2016)

Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy
por: Ruff, Kevin J, et al.
Publicado: (2015)

Shikonin Inhibits Fin Regeneration in Zebrafish Larvae
por: Cao, Zigang, et al.
Publicado: (2022)

Shikonin ameliorates salivary gland damage and inflammation in a mouse model of Sjögren’s syndrome by modulating MAPK signaling pathway
por: Guo, Wenjing, et al.
Publicado: (2023)

Correction: Shikonin inhibits cancer cell cycling by targeting Cdc25s
por: Zhang, Shoude, et al.
Publicado: (2023)

Shikonin reduces endometriosis by inhibiting RANTES secretion and mononuclear macrophage chemotaxis
por: YUAN, DONG-PING, et al.
Publicado: (2014)

Successful in vivo hyperthermal therapy toward breast cancer by Chinese medicine shikonin-loaded thermosensitive micelle
por: Su, Yonghua, et al.
Publicado: (2017)

Sonosensitizer Nanoplatforms Augmented Sonodynamic Therapy-Sensitizing Shikonin-Induced Necroptosis Against Hepatocellular Carcinoma
por: Tian, Huimin, et al.
Publicado: (2023)

Berberine displays antitumor activity in esophageal cancer cells in vitro
por: Jiang, Shu-Xian, et al.
Publicado: (2017)

Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction
por: Wang, Fangfang, et al.
Publicado: (2020)

In vitro and in vivo efficacy of thiacloprid against Echinococcus multilocularis
por: Liu, Chuanchuan, et al.
Publicado: (2021)

In vivo and in vitro efficacy of crocin against Echinococcus multilocularis
por: Liu, Chuanchuan, et al.
Publicado: (2021)

An Oxidative Stress Mechanism of Shikonin in Human Glioma Cells
por: Yang, Jen-Tsung, et al.
Publicado: (2014)

Mechanisms Behind the Inhibition of Lung Adenocarcinoma Cell by Shikonin
por: Lan, Wenjing, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_adnhuppl14ianpos8j28cqefug