An Interleukin-6 Receptor Antibody Suppresses Atherosclerosis in Atherogenic Mice

IκBNS is a nuclear IκB protein which negatively regulates nuclear factor-κB activity. We demonstrated that IκBNS deficiency accelerates atherosclerosis in LDL receptor-deficient (LDLr(−/−)) mice via increased interleukin (IL)-6 production by macrophages. Previous studies showed that the increase in...

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Detalles Bibliográficos
Autores principales: Akita, Koji, Isoda, Kikuo, Sato-Okabayashi, Yayoi, Kadoguchi, Tomoyasu, Kitamura, Kenichi, Ohtomo, Fumie, Shimada, Kazunori, Daida, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743912/
https://www.ncbi.nlm.nih.gov/pubmed/29312959
http://dx.doi.org/10.3389/fcvm.2017.00084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743912/
https://www.ncbi.nlm.nih.gov/pubmed/29312959
http://dx.doi.org/10.3389/fcvm.2017.00084

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