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Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway

Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities. However, the biologic mechanisms have not been fully explored. In this study, BD exhibited more potent cytotoxic effect on pancreatic cancer (PanCa) cell lines, while exerted weaker cytotoxi...

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Detalles Bibliográficos
Autores principales:	Lai, Zheng-Quan, Ip, Siu-Po, Liao, Hui-Jun, Lu, Zheng, Xie, Jian-Hui, Su, Zi-Ren, Chen, Yun-Long, Xian, Yan-Fang, Leung, Po-Sing, Lin, Zhi-Xiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744014/ https://www.ncbi.nlm.nih.gov/pubmed/29311937 http://dx.doi.org/10.3389/fphar.2017.00936

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