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Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins

Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation of cellular process and have been identified as p...

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Autores principales: Tur, Mehmet Kemal, Daramola, Adebukola K., Gattenlöhner, Stefan, Herling, Marco, Chetty, Shivan, Barth, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744083/
https://www.ncbi.nlm.nih.gov/pubmed/28976934
http://dx.doi.org/10.3390/biomedicines5040059
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author Tur, Mehmet Kemal
Daramola, Adebukola K.
Gattenlöhner, Stefan
Herling, Marco
Chetty, Shivan
Barth, Stefan
author_facet Tur, Mehmet Kemal
Daramola, Adebukola K.
Gattenlöhner, Stefan
Herling, Marco
Chetty, Shivan
Barth, Stefan
author_sort Tur, Mehmet Kemal
collection PubMed
description Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation of cellular process and have been identified as positive mediators of apoptosis via extrinsic and intrinsic death-regulating signaling pathways. Tumor suppressor activities have been shown for DAPk1 and DAPk2 and they are downregulated in e.g., Hodgkin’s (HL) and B cell lymphoma (CLL), respectively. Here, we review a targeted therapeutic approach which involves reconstitution of DAPks by the generation of immunokinase fusion proteins. These recombinant proteins consist of a disease-specific ligand fused to a modified version of DAPk1 or DAPk2. HL was targeted via CD30 and B-CLL via CD22 cell surface antigens.
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spelling pubmed-57440832017-12-31 Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins Tur, Mehmet Kemal Daramola, Adebukola K. Gattenlöhner, Stefan Herling, Marco Chetty, Shivan Barth, Stefan Biomedicines Review Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation of cellular process and have been identified as positive mediators of apoptosis via extrinsic and intrinsic death-regulating signaling pathways. Tumor suppressor activities have been shown for DAPk1 and DAPk2 and they are downregulated in e.g., Hodgkin’s (HL) and B cell lymphoma (CLL), respectively. Here, we review a targeted therapeutic approach which involves reconstitution of DAPks by the generation of immunokinase fusion proteins. These recombinant proteins consist of a disease-specific ligand fused to a modified version of DAPk1 or DAPk2. HL was targeted via CD30 and B-CLL via CD22 cell surface antigens. MDPI 2017-10-04 /pmc/articles/PMC5744083/ /pubmed/28976934 http://dx.doi.org/10.3390/biomedicines5040059 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tur, Mehmet Kemal
Daramola, Adebukola K.
Gattenlöhner, Stefan
Herling, Marco
Chetty, Shivan
Barth, Stefan
Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins
title Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins
title_full Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins
title_fullStr Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins
title_full_unstemmed Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins
title_short Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins
title_sort restoration of dap kinase tumor suppressor function: a therapeutic strategy to selectively induce apoptosis in cancer cells using immunokinase fusion proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744083/
https://www.ncbi.nlm.nih.gov/pubmed/28976934
http://dx.doi.org/10.3390/biomedicines5040059
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