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Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A

Experimental renal cancer caused by ochratoxin A (OTA) in rats was first defined in the US National Toxicology Program (1989) and raised questions about any aetiological role in human urinary tract tumours. A review of histopathology in several rat kidney tumours from dietary OTA in recently describ...

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Autores principales: Herman, Diana, Mantle, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744104/
https://www.ncbi.nlm.nih.gov/pubmed/29182526
http://dx.doi.org/10.3390/toxins9120384
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author Herman, Diana
Mantle, Peter
author_facet Herman, Diana
Mantle, Peter
author_sort Herman, Diana
collection PubMed
description Experimental renal cancer caused by ochratoxin A (OTA) in rats was first defined in the US National Toxicology Program (1989) and raised questions about any aetiological role in human urinary tract tumours. A review of histopathology in several rat kidney tumours from dietary OTA in recently described London studies, augmented by clinical immunohistochemistry for the first time for this mycotoxin, establishes their renal tubular cell origin. It had been assumed that the toxin might cause the human urothelial tumours associated with Balkan endemic nephropathy, but the present study could not support this. Comparison with a similar review of a metastasising renal tumour from a female rat of the NTP study consistently shows the kidney as the primary carcinogenic site for OTA. Morphological heterogeneity of these kidney tumours as epithelioid and/or sarcomatoid is revealed. Leiomyosarcoma was also diagnosed, and rhabdomyosarcoma differentiation was observed in the exceptionally aggressive NTP female tumour. The present pilot study involving immunohistochemistry indicates need for wider review of archived tumours for experimental evidence before formulating any epidemiological basis from a rat model for OTA’s relevance to idiopathic human renal cell carcinoma. Although the NTP study concluded that females are less sensitive to OTA than males, some female tumours still had heterogeneous morphology.
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spelling pubmed-57441042017-12-31 Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A Herman, Diana Mantle, Peter Toxins (Basel) Article Experimental renal cancer caused by ochratoxin A (OTA) in rats was first defined in the US National Toxicology Program (1989) and raised questions about any aetiological role in human urinary tract tumours. A review of histopathology in several rat kidney tumours from dietary OTA in recently described London studies, augmented by clinical immunohistochemistry for the first time for this mycotoxin, establishes their renal tubular cell origin. It had been assumed that the toxin might cause the human urothelial tumours associated with Balkan endemic nephropathy, but the present study could not support this. Comparison with a similar review of a metastasising renal tumour from a female rat of the NTP study consistently shows the kidney as the primary carcinogenic site for OTA. Morphological heterogeneity of these kidney tumours as epithelioid and/or sarcomatoid is revealed. Leiomyosarcoma was also diagnosed, and rhabdomyosarcoma differentiation was observed in the exceptionally aggressive NTP female tumour. The present pilot study involving immunohistochemistry indicates need for wider review of archived tumours for experimental evidence before formulating any epidemiological basis from a rat model for OTA’s relevance to idiopathic human renal cell carcinoma. Although the NTP study concluded that females are less sensitive to OTA than males, some female tumours still had heterogeneous morphology. MDPI 2017-11-28 /pmc/articles/PMC5744104/ /pubmed/29182526 http://dx.doi.org/10.3390/toxins9120384 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Herman, Diana
Mantle, Peter
Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A
title Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A
title_full Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A
title_fullStr Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A
title_full_unstemmed Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A
title_short Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A
title_sort immunohistochemical analysis of rat renal tumours caused by ochratoxin a
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744104/
https://www.ncbi.nlm.nih.gov/pubmed/29182526
http://dx.doi.org/10.3390/toxins9120384
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