High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans

The Genome Aggregation Database presently contains >120,000 human genomes. We searched in this database for the presence of mutations at the sites of tetanus (TeNT) and botulinum neurotoxins (BoNTs) cleavages of the three SNARE proteins: VAMP, SNAP-25 and Syntaxin. These mutations could account f...

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Detalles Bibliográficos
Autores principales: Carle, Stefan, Pirazzini, Marco, Rossetto, Ornella, Barth, Holger, Montecucco, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744124/
https://www.ncbi.nlm.nih.gov/pubmed/29257047
http://dx.doi.org/10.3390/toxins9120404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744124/
https://www.ncbi.nlm.nih.gov/pubmed/29257047
http://dx.doi.org/10.3390/toxins9120404

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