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Rodent Papillomaviruses

Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilize...

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Detalles Bibliográficos
Autores principales: Uberoi, Aayushi, Lambert, Paul F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744137/
https://www.ncbi.nlm.nih.gov/pubmed/29186900
http://dx.doi.org/10.3390/v9120362
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author Uberoi, Aayushi
Lambert, Paul F.
author_facet Uberoi, Aayushi
Lambert, Paul F.
author_sort Uberoi, Aayushi
collection PubMed
description Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilized resources in the field of papillomavirus biology. Two rodent papillomaviruses, MnPV1, which infects the Mastomys species of multimammate rats, and MmuPV1, which infects laboratory mice, are currently the most studied rodent PVs. Both of these viruses cause malignancy in the skin and can provide attractive infection models to study the lesser understood cutaneous papillomaviruses that have been frequently associated with HPV-related skin cancers. Of these, MmuPV1 is the first reported rodent papillomavirus that can naturally infect the laboratory strain of mice. MmuPV1 is an attractive model virus to study papillomavirus pathogenesis because of the ubiquitous availability of lab mice and the fact that this mouse species is genetically modifiable. In this review, we have summarized the knowledge we have gained about PV biology from the study of rodent papillomaviruses and point out the remaining gaps that can provide new research opportunities.
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spelling pubmed-57441372017-12-31 Rodent Papillomaviruses Uberoi, Aayushi Lambert, Paul F. Viruses Review Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilized resources in the field of papillomavirus biology. Two rodent papillomaviruses, MnPV1, which infects the Mastomys species of multimammate rats, and MmuPV1, which infects laboratory mice, are currently the most studied rodent PVs. Both of these viruses cause malignancy in the skin and can provide attractive infection models to study the lesser understood cutaneous papillomaviruses that have been frequently associated with HPV-related skin cancers. Of these, MmuPV1 is the first reported rodent papillomavirus that can naturally infect the laboratory strain of mice. MmuPV1 is an attractive model virus to study papillomavirus pathogenesis because of the ubiquitous availability of lab mice and the fact that this mouse species is genetically modifiable. In this review, we have summarized the knowledge we have gained about PV biology from the study of rodent papillomaviruses and point out the remaining gaps that can provide new research opportunities. MDPI 2017-11-27 /pmc/articles/PMC5744137/ /pubmed/29186900 http://dx.doi.org/10.3390/v9120362 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Uberoi, Aayushi
Lambert, Paul F.
Rodent Papillomaviruses
title Rodent Papillomaviruses
title_full Rodent Papillomaviruses
title_fullStr Rodent Papillomaviruses
title_full_unstemmed Rodent Papillomaviruses
title_short Rodent Papillomaviruses
title_sort rodent papillomaviruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744137/
https://www.ncbi.nlm.nih.gov/pubmed/29186900
http://dx.doi.org/10.3390/v9120362
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