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The Interplay between Natural Killer Cells and Human Herpesvirus-6

Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. Both are lymphotropic viruses that establish latency in the host. The ability to evade the immune responses of effector cells is likely a major factor contributing to the development of a persisten...

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Autores principales: Eliassen, Eva, Di Luca, Dario, Rizzo, Roberta, Barao, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744142/
https://www.ncbi.nlm.nih.gov/pubmed/29194419
http://dx.doi.org/10.3390/v9120367
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author Eliassen, Eva
Di Luca, Dario
Rizzo, Roberta
Barao, Isabel
author_facet Eliassen, Eva
Di Luca, Dario
Rizzo, Roberta
Barao, Isabel
author_sort Eliassen, Eva
collection PubMed
description Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. Both are lymphotropic viruses that establish latency in the host. The ability to evade the immune responses of effector cells is likely a major factor contributing to the development of a persistent HHV-6A/B (collectively termed HHV-6) infection. Natural killer (NK) cells are lymphocytes that, along with neutrophils and monocytes/macrophages, participate in the critical innate immune response during viral infections, but can also mediate the antigen-specific memory responses generally associated with adaptive immunity. NK cells compose the first barrier that viruses must break through to continue replication and dissemination, and a weak NK cell response may predispose an individual to chronic viral infections. Both HHV-6A and HHV-6B can interfere with NK cell-mediated anti-viral responses but the mechanisms by which each of these viruses affect NK cell activity differs. In this review, we will explore the nuanced relationships between the two viruses and NK cells, discussing, in addition, relevant disease associations.
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spelling pubmed-57441422017-12-31 The Interplay between Natural Killer Cells and Human Herpesvirus-6 Eliassen, Eva Di Luca, Dario Rizzo, Roberta Barao, Isabel Viruses Review Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. Both are lymphotropic viruses that establish latency in the host. The ability to evade the immune responses of effector cells is likely a major factor contributing to the development of a persistent HHV-6A/B (collectively termed HHV-6) infection. Natural killer (NK) cells are lymphocytes that, along with neutrophils and monocytes/macrophages, participate in the critical innate immune response during viral infections, but can also mediate the antigen-specific memory responses generally associated with adaptive immunity. NK cells compose the first barrier that viruses must break through to continue replication and dissemination, and a weak NK cell response may predispose an individual to chronic viral infections. Both HHV-6A and HHV-6B can interfere with NK cell-mediated anti-viral responses but the mechanisms by which each of these viruses affect NK cell activity differs. In this review, we will explore the nuanced relationships between the two viruses and NK cells, discussing, in addition, relevant disease associations. MDPI 2017-12-01 /pmc/articles/PMC5744142/ /pubmed/29194419 http://dx.doi.org/10.3390/v9120367 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Eliassen, Eva
Di Luca, Dario
Rizzo, Roberta
Barao, Isabel
The Interplay between Natural Killer Cells and Human Herpesvirus-6
title The Interplay between Natural Killer Cells and Human Herpesvirus-6
title_full The Interplay between Natural Killer Cells and Human Herpesvirus-6
title_fullStr The Interplay between Natural Killer Cells and Human Herpesvirus-6
title_full_unstemmed The Interplay between Natural Killer Cells and Human Herpesvirus-6
title_short The Interplay between Natural Killer Cells and Human Herpesvirus-6
title_sort interplay between natural killer cells and human herpesvirus-6
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744142/
https://www.ncbi.nlm.nih.gov/pubmed/29194419
http://dx.doi.org/10.3390/v9120367
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